TIBSOVO

Ivosidenib 250mg, Oral tablet

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not ingest Grapefruit or Grapefruit Juice while on Ivosidenib therapy. Side effects from Ivosidenib may get worse if you take Grapefruit Juice or grapefruit-containing foods. Contact your prescriber immediately if you experience chest pain, dizziness, fainting or falling spells, palpitations, shortness of breath, or a change in your heartbeat (such as a fast or irregular heartbeat).

· Notes for Professionals: Advise patients to avoid grapefruit juice while taking ivosidenib due to increased plasma concentrations of ivosidenib, which increases the risk of QT prolongation or other toxicities. Ivosidenib is a CYP3A4 substrate and grapefruit juice is a strong CYP3A4 inhibitor. Coadministration with another strong CYP3A4 inhibitor increased ivosidenib single-dose AUC to 269% of control, with no change in Cmax.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>