Potassium iodide (KI) is an oral compound comprised of roughly 76% iodine and 23% potassium by weight. Clinically, iodine has been used as a therapeutic agent since the 1800s, most notably in the treatment of thyroid disease. Potassium iodide is used as an adjunct to other antithyroid agents in the treatment of hyperthyroidism and thyrotoxicosis, and preoperatively to induce thyroid involution. The drug is also useful as a protectant of the thyroid gland following radiation exposure. Certain potassium iodide formulations (e.g., Iostat, ThyroSafe, ThyroShield), received FDA clearance for thyroid protection against radioactive iodine exposure (e.g., in the event of a nuclear plant accident or 'dirty bomb' containing radioactive iodine, I-131). These formulations may be distributed to high-risk individuals by the government or public health officials and are also approved for OTC sale to the general public. The U.S. government actively distributes stockpiles of KI tablets to those States that house nuclear reactors. Clinicians should note that FDA-approved potassium iodide products only provide protection for the thyroid gland from radioiodines, and do not provide protection against other types of radiation exposure. Potassium iodide (KI) appears useful for dermatologic conditions; the drug has demonstrated efficacy for cutaneous and lymphocutaneous sporotrichosis and is used in the tropics to treat entomophthoramycosis caused by the fungi Basidiobolus and Conidiobolus. The drug is also used off-label as a second line agent for various inflammatory dermatoses, including erythema nodosum, subacute nodular migratory panniculitis, nodular vasculitis, erythema multiforme, and Sweet's syndrome. Although potassium iodide was commonly used historically as a respiratory expectorant, the drug is no longer recommended for this purpose due to a lack of evidence for clinical efficacy and the potential for thyroid dysfunction or other side effects. Commercial products containing potassium iodide have been marketed for medical use since 1939.
General Administration Information
For storage information, see the specific product information within the How Supplied section.
NOTE: Enteric-coated potassium iodide tablets have been associated with severe complications which have resulted in death and are not recommended for use.
Route-Specific Administration
Oral Administration
-All dosage forms: To minimize GI irritation, administer after meals or with milk.
Oral Solid Formulations
Oral tablets:
-Potassium iodide tablets are used only for the treatment of radiation emergencies.
Oral Liquid Formulations
Saturated Solution of Potassium Iodide (SSKI) oral solution 1 gram/mL:
-Administer using a calibrated measuring device (e.g., the provided dropper) to ensure accurate dosing.
-Mix dose in 240 mL of water, fruit juice, or milk prior to administration.
-To minimize gastric irritation, administer with food or milk.
-SSKI solution is normally clear and colorless. A slightly darkened solution does not indicate loss of potency. If the solution turns brownish-yellow in color, it should be discarded. The saturated solutions may crystallize on exposure to cold temperatures; allowing to warm to room temperature with shaking may redissolve crystals.
Potassium Iodide oral solutions or syrups (65 mg/mL):
-Administer using a calibrated measuring device (e.g., the provided dropper) to ensure accurate dosing.
-When used for radiation emergencies: Administer once every day (every 24 hours) as directed by public officials. Do not administer more than 1 dose in 24 hours.
Extemporaneous compounding instructions for potassium iodide liquid mixture (8.125 mg/5 mL or 16.25 mg/5 mL):
-Put either one 65 mg or one 130 mg potassium iodide tablet into a small bowl and grind it into a fine powder using the back of a metal teaspoon against the inside of the bowl. The powder should not have any large pieces.
-Add 4 teaspoonfuls of water to the crushed powder in the bowl and mix until the potassium iodide powder is dissolved in the water.
-Mix the potassium iodide water solution with 4 teaspoonfuls of low fat white or chocolate milk, orange juice, flat soda, raspberry syrup, or infant formula.
-NOTE: If a 65 mg tablet was used, the concentration is 8.125 mg potassium iodide/5 mL. If a 130 mg tablet was used, the concentration is 16.25 mg potassium iodide/5 mL.
-Storage: May be stored for up to 7 days in the refrigerator. Discard any unused portions.
Gastric disturbances occur frequently with potassium iodide therapy and include stomach upset, stomach pain, swelling or tenderness of the salivary gland (sialadenitis), nausea, vomiting, and diarrhea. Discontinuation of this drug may be required if these adverse reactions persist or become severe. GI bleeding is a less frequently reported adverse reaction.
Dermatologic reactions, such as acneiform rash, can occur from prolonged use of potassium iodide. Prolonged use may also result in goiter, thyroid adenoma, or hypothyroidism.
Iodine toxicity, or iodism, can occur from prolonged use or excessive doses of potassium iodide. Symptoms include metallic taste, sore gums, teeth, and mouth, burning in the throat or mouth, ulcerated mucous membranes, acute rhinitis, sneezing, and ocular irritation with swelling of the eyelids (blepharedema). Severe headache, productive cough, pulmonary edema, and tenderness and swelling of the parotid and submaxillary glands may also occur. If symptoms of iodism develop, discontinue use and initiate appropriate supportive therapy.
Potassium iodide therapy may result in a hypersensitivity reaction. These reactions may manifest as angioedema, dysphagia, wheezing, cutaneous and mucosal hemorrhage, and signs and symptoms similar to serum sickness, such as fever, arthralgia, lymphadenopathy, and eosinophilia.
If possible, use of potassium iodide should be avoided in patients with iodine hypersensitivity. Patients at an increased risk of developing adverse effects caused by iodine include those with dermatitis herpetiformis, hypocomplementemic vasculitis, goiter, or autoimmune thyroid disease.
Potassium iodide, KI crosses the placenta in amounts sufficient to cause fetal harm, fetal goiter and abnormal thyroid function during human pregnancy. Potassium iodide therapy is used during pregnancy when medically necessary for thyroid protection or hyperthyroid emergencies; use as an expectorant is not advised. Because of the possible development of fetal goiter, if the drug is used during pregnancy or if a female of childbearing potential becomes pregnant during therapy, apprise the patient of the potential hazard. Prolonged use for thyroid disease during pregnancy is not advised, however, potassium iodide has been used short term (e.g., 10 days) to manage labor-induced thyrotoxic crisis and as treatment prior to thyroidectomy in pregnant women. Women should not self-supplement with potassium iodide during pregnancy.
Potassium iodide, KI is excreted into breast milk. Rash or thyroid suppression can possibly occur in the nursing infant. Potassium iodide therapy would only be used in a lactating woman when medically necessary for thyroid protection or hyperthyroid emergencies; use as an expectorant is not advised. Breast-feeding women should take potassium iodide if they are contaminated with radioactive iodine and advised to do so by their governmental agencies, according to current guidelines for radiation emergencies. The normal amount of potassium iodide present in human breast milk is not sufficient to protect an infant who has been exposed to radioactive Iodine-131. Thus, in an environmental exposure, the breast-feeding infant must receive supplemental potassium iodide to block uptake of radiation in the infant's thyroid gland.
Potassium iodide should be used with caution in patients with sulfite hypersensitivity and/or asthma because some formulations of this drug contain sodium bisulfite. A higher frequency of sensitivity reactions occur in asthmatic patients compared to nonasthmatic patients. Potassium iodide should be used cautiously in patients with acute bronchitis.
Potassium iodide should be used cautiously in patients with renal impairment. Due to impaired renal filtering of electrolytes, an increase in serum potassium can occur. Potassium iodide can also exacerbate pre-existing hyperkalemia or myotonia congenita (Thomsen's disease). Serum potassium and potential signs and symptoms of potassium toxicity should be monitored. Potassium iodide should also be used with extreme caution in the following circumstances: acute dehydration, muscle cramps, adrenal insufficiency, and cardiac disease.
Potassium iodide should be used with extreme caution in patients with tuberculosis because pulmonary irritation and increased secretions may ensue. If possible, potassium iodide should be avoided in this patient population.
Potassium iodide should be used with caution in patients with acne vulgaris. The product can produce an acneiform rash or aggravate existing acne.
This drug may also have activity against the following microorganisms: Sporothrix schenckii
NOTE: Some organisms may not have been adequately studied during clinical trials; therefore, exclusion from this list does not necessarily negate the drug's activity against the organism.
For the treatment of thyrotoxicosis*, including thyroid storm*:
Oral dosage (saturated oral solution of potassium iodide containing 1 g/mL):
Adults: 250 mg PO every 6 hours. Do not start until 1 hour after antithyroid drugs.
Infants, Children, and Adolescents: 50 to 250 mg PO every 8 hours. Do not start until 1 hour after antithyroid drugs.
For thyroid involution induction* in persons with Graves' disease* prior to thyroidectomy:
Oral dosage (saturated oral solution of potassium iodide containing 1 g/mL):
Adults: 50 to 100 mg PO every 8 hours for 10 days before thyroidectomy when it is not possible to render a person with Grave's disease euthyroid before thyroidectomy, thyroidectomy is urgent, or when the person is allergic to antithyroid drugs.
Infants, Children, and Adolescents: 50 to 200 mg PO every 8 hours for 7 to 14 days before thyroidectomy when it is not possible to render a person with Grave's disease euthyroid before thyroidectomy, thyroidectomy is urgent, or when the person is allergic to antithyroid drugs.
For emergency use as a thyroid protectant in a radiation exposure involving radioactive iodine:
Oral dosage (65 mg and 130 mg tablet or 65 mg/mL oral solution):
Adults: 130 mg PO once daily, taken as soon as possible after exposure. The effectiveness of potassium iodide as a specific blocker of thyroid radioiodine uptake is well established, with the benefits of each dose lasting approximately 24 hours. Daily treatment should continue until public officials have determined it is safe to discontinue therapy. In general, daily dosing should continue until the risk of exposure has passed or until other adjunctive measures (e.g., evacuation, sheltering, and control of the food and milk supply) have been successfully implemented. The FDA emphasizes that the overall benefits of potassium iodide far exceed the risk of overdosing in this situation.
Pregnant or Lactating females: 130 mg PO once, taken as soon as possible after exposure. Women who are pregnant or breast-feeding should consult with a healthcare provider before taking repeated doses. Particular attention should be paid to the dose and duration of treatment for women who are pregnant. The FDA has specifically recommended that pregnant women be given priority with regard to adjunctive measures like evacuation in order to obviate the need for repeat dosing with potassium iodide. The protective effects of a single dose lasts approximately 24 hours.
Adolescents who weigh at least 70 kg (150 pounds): 130 mg PO once daily, taken as soon as possible after exposure. The effectiveness of potassium iodide as a specific blocker of thyroid radioiodine uptake is well established, with the benefits of each dose lasting approximately 24 hours. Daily treatment should continue until public officials have determined it is safe to discontinue therapy. In general, daily dosing should continue until the risk of exposure has passed or until other adjunctive measures (e.g., evacuation, sheltering, and control of the food and milk supply) have been successfully implemented. The FDA emphasizes that the overall benefits of potassium iodide far exceed the risk of overdosing in this situation.
Adolescents weighing less than 70 kg (150 pounds): 65 mg PO once daily, taken as soon as possible after exposure. The effectiveness of potassium iodide as a specific blocker of thyroid radioiodine uptake is well established, with the benefits of each dose lasting approximately 24 hours. Daily treatment should continue until public officials have determined it is safe to discontinue therapy. In general, daily dosing should continue until the risk of exposure has passed or until other adjunctive measures (e.g., evacuation, sheltering, and control of the food and milk supply) have been successfully implemented. The FDA emphasizes that the overall benefits of potassium iodide far exceed the risk of overdosing in this situation.
Children 4 to 12 years: 65 mg PO once daily, taken as soon as possible after exposure. The effectiveness of potassium iodide as a specific blocker of thyroid radioiodine uptake is well established, with the benefits of each dose lasting approximately 24 hours. Daily treatment should continue until public officials have determined it is safe to discontinue therapy. In general, daily dosing should continue until the risk of exposure has passed or until other adjunctive measures (e.g., evacuation, sheltering, and control of the food and milk supply) have been successfully implemented. The FDA emphasizes that the overall benefits of potassium iodide far exceed the risk of overdosing in this situation.
Infants and Children age 2 months to 3 years: 32.5 mg PO once daily, taken as soon as possible after exposure. The effectiveness of potassium iodide as a specific blocker of thyroid radioiodine uptake is well established, with the benefits of each dose lasting approximately 24 hours. Daily treatment should continue until public officials have determined it is safe to discontinue therapy. In general, daily dosing should continue until the risk of exposure has passed or until other adjunctive measures (e.g., evacuation, sheltering, and control of the food and milk supply) have been successfully implemented. The FDA emphasizes that the overall benefits of potassium iodide far exceed the risk of overdosing in this situation.
Neonates and Infants through 1 month of age: 16.25 mg PO once, taken as soon as possible after exposure. Consult with a healthcare provider before administering repeated doses. The FDA has specifically recommended that newborns be given priority with regard to adjunctive measures (like evacuation) in order to obviate the need for repeat dosing with potassium iodide. The protective effects of a single dose lasts approximately 24 hours.
For the treatment of cutaneous or lymphocutaneous sporotrichosis*:
Oral dosage (saturated oral solution of potassium iodide, 1 g/mL, e.g., SSKI):
Adults: 5 drops PO 3 times daily, initially. Increase as tolerated to 40 to 50 drops PO 3 times daily for 2 to 4 weeks after all lesions have resolved, usually for a total of 3 to 6 months in patients who do not respond to itraconazole.
Infants, Children, and Adolescents: 1 drop PO 3 times daily, initially. Increase as tolerated to 1 drop/kg/dose (Max: 40 to 50 drops/dose) PO 3 times daily, whichever is lower, for 2 to 4 weeks after all lesions have resolved, usually for a total of 3 to 6 months in patients who do not respond to itraconazole.
For short-term use as an expectorant in the symptomatic treatment of chronic pulmonary diseases where tenacious mucus complicates the problem, such as chronic bronchitis and pulmonary emphysema:
Oral dosage (saturated oral solution of potassium iodide containing 1 gram per mL, e.g., SSKI):
Adults: 0.3 mL (300 mg) or 0.6 mL (600 mg) PO 3 to 4 times daily, diluted in a glassful of water, fruit juice, or milk. Use no longer than necessary to produce the desired effect. Although this recommendation is found in the manufacturer label, this drug has not been found by FDA to be safe and effective for this purpose has not been approved by the FDA's drug approval process. Due to the potential for adverse effects and lack of evidence of proven efficacy, guidelines do not recommend the use of iodinated products for the treatment of cough or expectoration.
Maximum Dosage Limits:
Dosage must be individualized to the indication for use, patient age, and clinical response.
Patients with Hepatic Impairment Dosing
Specific information is not available; however, it appears no dosage adjustment is needed.
Patients with Renal Impairment Dosing
Dosage should be modified depending on clinical response and degree of renal impairment.
*non-FDA-approved indication
Acetaminophen; Ibuprofen: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Aliskiren: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and aliskiren are used together. Concomitant use may increase the risk of hyperkalemia.
Aliskiren; Hydrochlorothiazide, HCTZ: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and aliskiren are used together. Concomitant use may increase the risk of hyperkalemia.
Amiloride: (Major) The use of potassium supplements in patients treated with amiloride is generally contraindicated. Concomitant use may increase the risk of hyperkalemia. If potassium supplementation is used, monitor serum potassium concentrations closely.
Amiloride; Hydrochlorothiazide, HCTZ: (Major) The use of potassium supplements in patients treated with amiloride is generally contraindicated. Concomitant use may increase the risk of hyperkalemia. If potassium supplementation is used, monitor serum potassium concentrations closely.
Amlodipine; Benazepril: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin-converting enzyme inhibitors (ACE inhibitors) are used together. Concomitant use may increase the risk of hyperkalemia.
Amlodipine; Celecoxib: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Amlodipine; Olmesartan: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Amlodipine; Valsartan: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Amlodipine; Valsartan; Hydrochlorothiazide, HCTZ: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Angiotensin II receptor antagonists: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Angiotensin-converting enzyme inhibitors: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin-converting enzyme inhibitors (ACE inhibitors) are used together. Concomitant use may increase the risk of hyperkalemia.
Atropine; Difenoxin: (Moderate) Drugs that decrease GI motility, like diphenoxylate/difenoxin, may increase the risk of GI irritation from sustained-release solid oral dosage forms of potassium salts. Immediate release potassium formulations may be preferred in patients requiring diphenoxylate/difenoxin therapy.
Azilsartan: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Azilsartan; Chlorthalidone: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Benazepril: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin-converting enzyme inhibitors (ACE inhibitors) are used together. Concomitant use may increase the risk of hyperkalemia.
Benazepril; Hydrochlorothiazide, HCTZ: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin-converting enzyme inhibitors (ACE inhibitors) are used together. Concomitant use may increase the risk of hyperkalemia.
Bupivacaine; Meloxicam: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Candesartan: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Candesartan; Hydrochlorothiazide, HCTZ: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Captopril: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin-converting enzyme inhibitors (ACE inhibitors) are used together. Concomitant use may increase the risk of hyperkalemia.
Captopril; Hydrochlorothiazide, HCTZ: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin-converting enzyme inhibitors (ACE inhibitors) are used together. Concomitant use may increase the risk of hyperkalemia.
Celecoxib: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Celecoxib; Tramadol: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Chlorpheniramine; Ibuprofen; Pseudoephedrine: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Cyclosporine: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and cyclosporine are used together. Concomitant use may increase the risk of hyperkalemia.
Diclofenac: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Diclofenac; Misoprostol: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Diflunisal: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Digoxin: (Minor) Potassium levels should be monitored closely in patients receiving digoxin and potassium supplementation. Both hypokalemia and hyperkalemia increase the risk of digoxin toxicity. Some patients at increased risk are patients with renal impairment, patients on diuretics, and patients who are on potassium-sparing medications concurrently. Monitor renal function, potassium concentrations, and digoxin concentrations and clinical response during concurrent treatment.
Diphenhydramine; Ibuprofen: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Diphenhydramine; Naproxen: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Diphenoxylate; Atropine: (Moderate) Drugs that decrease GI motility, like diphenoxylate/difenoxin, may increase the risk of GI irritation from sustained-release solid oral dosage forms of potassium salts. Immediate release potassium formulations may be preferred in patients requiring diphenoxylate/difenoxin therapy.
Drospirenone: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and drospirenone are used together. Concomitant use may increase the risk of hyperkalemia. Drospirenone has anti-mineralocorticoid activity, including the potential for hyperkalemia in high-risk patients, comparable to 25 mg of spironolactone.
Drospirenone; Estetrol: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and drospirenone are used together. Concomitant use may increase the risk of hyperkalemia. Drospirenone has anti-mineralocorticoid activity, including the potential for hyperkalemia in high-risk patients, comparable to 25 mg of spironolactone.
Drospirenone; Estradiol: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and drospirenone are used together. Concomitant use may increase the risk of hyperkalemia. Drospirenone has anti-mineralocorticoid activity, including the potential for hyperkalemia in high-risk patients, comparable to 25 mg of spironolactone.
Drospirenone; Ethinyl Estradiol: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and drospirenone are used together. Concomitant use may increase the risk of hyperkalemia. Drospirenone has anti-mineralocorticoid activity, including the potential for hyperkalemia in high-risk patients, comparable to 25 mg of spironolactone.
Drospirenone; Ethinyl Estradiol; Levomefolate: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and drospirenone are used together. Concomitant use may increase the risk of hyperkalemia. Drospirenone has anti-mineralocorticoid activity, including the potential for hyperkalemia in high-risk patients, comparable to 25 mg of spironolactone.
Enalapril, Enalaprilat: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin-converting enzyme inhibitors (ACE inhibitors) are used together. Concomitant use may increase the risk of hyperkalemia.
Enalapril; Hydrochlorothiazide, HCTZ: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin-converting enzyme inhibitors (ACE inhibitors) are used together. Concomitant use may increase the risk of hyperkalemia.
Eplerenone: (Contraindicated) The use of potassium supplements in patients receiving eplerenone for the treatment of hypertension is contraindicated. Concomitant use may increase the risk of hyperkalemia. Minimize the risk of hyperkalemia with proper patient selection and monitoring.
Eprosartan: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Eprosartan; Hydrochlorothiazide, HCTZ: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Etodolac: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Fenoprofen: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Finerenone: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and finerenone are used together. Concomitant use may increase the risk of hyperkalemia.
Flurbiprofen: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Fosinopril: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin-converting enzyme inhibitors (ACE inhibitors) are used together. Concomitant use may increase the risk of hyperkalemia.
Fosinopril; Hydrochlorothiazide, HCTZ: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin-converting enzyme inhibitors (ACE inhibitors) are used together. Concomitant use may increase the risk of hyperkalemia.
Hydrochlorothiazide, HCTZ; Moexipril: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin-converting enzyme inhibitors (ACE inhibitors) are used together. Concomitant use may increase the risk of hyperkalemia.
Hydrocodone; Ibuprofen: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Ibuprofen: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Ibuprofen; Famotidine: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Ibuprofen; Oxycodone: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Ibuprofen; Pseudoephedrine: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Indomethacin: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Iodoquinol: (Moderate) Iodoquinol should be used with caution in patients treated with thyroid agents. Iodine-containing compounds like iodoquinol may result in overt thyroid disease.
Irbesartan: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Irbesartan; Hydrochlorothiazide, HCTZ: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Ketoprofen: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Ketorolac: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Levothyroxine: (Moderate) Antithyroid agents should generally not be administered with the thyroid hormones due to their opposing effects. However, in selected cases some clinicians coadminister T4 (e.g., levothyroxine) to circumvent drug-induced hypothyroidism when large suppressive doses of antithyroid agents are administered for long periods of time. However, clinical and biochemical euthyroid status may usually be maintained with careful titration of the antithyroid agent dosage alone.
Levothyroxine; Liothyronine (Porcine): (Moderate) Antithyroid agents should generally not be administered with the thyroid hormones due to their opposing effects. However, in selected cases some clinicians coadminister T4 (e.g., levothyroxine) to circumvent drug-induced hypothyroidism when large suppressive doses of antithyroid agents are administered for long periods of time. However, clinical and biochemical euthyroid status may usually be maintained with careful titration of the antithyroid agent dosage alone.
Levothyroxine; Liothyronine (Synthetic): (Moderate) Antithyroid agents should generally not be administered with the thyroid hormones due to their opposing effects. However, in selected cases some clinicians coadminister T4 (e.g., levothyroxine) to circumvent drug-induced hypothyroidism when large suppressive doses of antithyroid agents are administered for long periods of time. However, clinical and biochemical euthyroid status may usually be maintained with careful titration of the antithyroid agent dosage alone.
Liothyronine: (Moderate) Antithyroid agents should generally not be administered with the thyroid hormones due to their opposing effects. However, in selected cases some clinicians coadminister T4 (e.g., levothyroxine) to circumvent drug-induced hypothyroidism when large suppressive doses of antithyroid agents are administered for long periods of time. However, clinical and biochemical euthyroid status may usually be maintained with careful titration of the antithyroid agent dosage alone.
Lisinopril: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin-converting enzyme inhibitors (ACE inhibitors) are used together. Concomitant use may increase the risk of hyperkalemia.
Lisinopril; Hydrochlorothiazide, HCTZ: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin-converting enzyme inhibitors (ACE inhibitors) are used together. Concomitant use may increase the risk of hyperkalemia.
Lithium: (Moderate) Lithium can precipitate goiter and/or hypothyroidism. Concomitant use of lithium and potassium iodide, KI can increase the likelihood of this adverse reaction.
Losartan: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Losartan; Hydrochlorothiazide, HCTZ: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Meclofenamate Sodium: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Mefenamic Acid: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Meloxicam: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Methimazole: (Moderate) Potassium iodide should not be used concurrently with other antithyroid agents. Agents such as methimazole and propylthiouracil, PTU can increase the likelihood of hypothyroidism when used in combination with potassium iodide.
Moexipril: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin-converting enzyme inhibitors (ACE inhibitors) are used together. Concomitant use may increase the risk of hyperkalemia.
Nabumetone: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Naproxen: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Naproxen; Esomeprazole: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Naproxen; Pseudoephedrine: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Nebivolol; Valsartan: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Nonsteroidal antiinflammatory drugs: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Olmesartan: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Olmesartan; Amlodipine; Hydrochlorothiazide, HCTZ: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Olmesartan; Hydrochlorothiazide, HCTZ: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Oxaprozin: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Penicillin G: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and high doses of penicillin G potassium are used together. Concomitant use may increase the risk for hyperkalemia. Penicillin G potassium contains 1.7 mEq of potassium per million units of penicillin G activity.
Perindopril: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin-converting enzyme inhibitors (ACE inhibitors) are used together. Concomitant use may increase the risk of hyperkalemia.
Perindopril; Amlodipine: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin-converting enzyme inhibitors (ACE inhibitors) are used together. Concomitant use may increase the risk of hyperkalemia.
Piroxicam: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Propylthiouracil, PTU: (Contraindicated) Potassium iodide should not be used concurrently with other antithyroid agents. Agents such as methimazole and propylthiouracil, PTU can increase the likelihood of hypothyroidism when used in combination with potassium iodide.
Quinapril: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin-converting enzyme inhibitors (ACE inhibitors) are used together. Concomitant use may increase the risk of hyperkalemia.
Quinapril; Hydrochlorothiazide, HCTZ: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin-converting enzyme inhibitors (ACE inhibitors) are used together. Concomitant use may increase the risk of hyperkalemia.
Ramipril: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin-converting enzyme inhibitors (ACE inhibitors) are used together. Concomitant use may increase the risk of hyperkalemia.
Sacubitril; Valsartan: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Sodium Iodide: (Contraindicated) The recent intake of antithyroid agents will affect the uptake of radioiodide from sodium iodide, I-131; patients must discontinue all medications and supplements that may interfere with iodide uptake into thyroid tissue prior to therapy with sodium iodide I-131. Various protocols are used. Many manufacturers state that concurrent antithyroid agents should be discontinued at least 3 to 4 days before administration of radioiodide. The following withdrawal timing recommendations were set forth in a procedure guideline published by the Society of Nuclear Medicine in February 2002. Antithyroid agents may affect iodide protein binding for an average of 5 days after administration; allow a 3 day wash out period for the antithyroid agent prior to sodium iodide I-131 administration. The antithyroid agent may be resumed 2 to 3 days after treatment.
Sodium Polystyrene Sulfonate: (Contraindicated) Sodium polystyrene sulfonate is indicated for the treatment of hyperkalemia. Administration of all potassium salts should be discontinued whenever therapy with sodium polystyrene sulfonate is indicated.
Sparsentan: (Moderate) Monitor potassium during concomitant use of sparsentan and potassium. Concomitant use increases the risk for hyperkalemia.
Spironolactone: (Major) The use of potassium supplements in patients receiving spironolactone may increase the risk for hyperkalemia. Potassium supplements should generally be avoided in heart failure patients receiving spironolactone. Monitor serum potassium concentrations closely if concomitant use is necessary.
Spironolactone; Hydrochlorothiazide, HCTZ: (Major) The use of potassium supplements in patients receiving spironolactone may increase the risk for hyperkalemia. Potassium supplements should generally be avoided in heart failure patients receiving spironolactone. Monitor serum potassium concentrations closely if concomitant use is necessary.
Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and trimethoprim are used together. Concomitant use may increase the risk of hyperkalemia.
Sulindac: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Sumatriptan; Naproxen: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Tacrolimus: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and tacrolimus are used together. Concomitant use may increase the risk of hyperkalemia.
Telmisartan: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Telmisartan; Amlodipine: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Telmisartan; Hydrochlorothiazide, HCTZ: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Thyroid hormones: (Moderate) Antithyroid agents should generally not be administered with the thyroid hormones due to their opposing effects. However, in selected cases some clinicians coadminister T4 (e.g., levothyroxine) to circumvent drug-induced hypothyroidism when large suppressive doses of antithyroid agents are administered for long periods of time. However, clinical and biochemical euthyroid status may usually be maintained with careful titration of the antithyroid agent dosage alone.
Tolmetin: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and nonsteroidal anti-inflammatory drugs (NSAIDs) are used together. Concomitant use may increase the risk of hyperkalemia.
Trandolapril: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin-converting enzyme inhibitors (ACE inhibitors) are used together. Concomitant use may increase the risk of hyperkalemia.
Trandolapril; Verapamil: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin-converting enzyme inhibitors (ACE inhibitors) are used together. Concomitant use may increase the risk of hyperkalemia.
Triamterene: (Major) The use of potassium supplements in patients treated with triamterene is generally contraindicated. Concomitant use may increase the risk of hyperkalemia. If potassium supplementation is used, monitor serum potassium concentrations closely.
Triamterene; Hydrochlorothiazide, HCTZ: (Major) The use of potassium supplements in patients treated with triamterene is generally contraindicated. Concomitant use may increase the risk of hyperkalemia. If potassium supplementation is used, monitor serum potassium concentrations closely.
Trimethoprim: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and trimethoprim are used together. Concomitant use may increase the risk of hyperkalemia.
Valsartan: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Valsartan; Hydrochlorothiazide, HCTZ: (Moderate) Monitor serum potassium concentrations closely if potassium supplements and angiotensin II receptor antagonists are used together. Concomitant use may increase the risk of hyperkalemia.
Potassium iodide (KI) supplies iodine systemically. The pharmacology of potassium iodide is not completely understood, despite years of use in clinical medicine for various medical conditions.
-Effects on the thyroid gland: Iodides are usually used in the treatment of hyperthyroidism to prepare patients for thyroidectomy. Iodides are also used along with antithyroid drugs and symptomatic treatments for the acute treatment of thyrotoxic crisis. By inhibiting thyroid hormone synthesis and release, thyroid gland vascularity is reduced, thyroid gland tissue becomes firmer, thyroid cell proliferation is reduced, follicular colloid reaccumulates, and bound iodine levels increase. The response of the hyperthyroid patient to iodide treatment is usually rapid, with symptomatic changes noted within 24 hours, although maximal effects may not be apparent until 2 weeks later. Although the effects may be noted for several weeks, iodides do not usually control the disease indefinitely, which is the reason why patients often need other measures (e.g., thyroidectomy) for treatment. The effects of iodides on the thyroid gland are complex, and can be dependent on the baseline thyroid status of the patient. Euthyroid patients or patients with certain underlying thyroid disorders may be at risk for iodine-induced hypothyroidism if they are exposed to large amounts of iodine systemically.
-Effects as a thyroid protectant prior to/following exposure to radioiodines: During a nuclear accident, various iodine isotopes are produced, including 131I, a radioactive iodine that concentrates in the thyroid gland. 131I has an 8-day half-life, which means that 99% of the radioactivity will decay in roughly 56 days. Potassium iodide (KI) is considered a safe and effective means by which to prevent radioiodine uptake by the thyroid gland and to minimize the risk of radiation-induced thyroid cancer. The administration of KI saturates the thyroid gland with iodine, minimizing the uptake of the radioactive isotope. For optimal protection against inhaled radioiodines following a radiation emergency, KI should be administered immediately coincident with the passage of the radioactive cloud, although KI may still have a substantial protective effect if taken 3 to 4 hours after the exposure.
-Effects in inflammatory dermatoses: The precise actions by which potassium iodide is therapeutically beneficial for various dermatologic conditions are not known. It appears that the drug may have some effects on inhibiting neutrophil chemotaxis, actions which might be beneficial in certain inflammatory dermatoses that display increased neutrophil activation in early stages of the disease. In dermatoses caused by yeast and fungi, potassium iodide appears to act as an antifungal, although it is not clear if the drug is directly fungicidal or works by enhancing the tissue and immune response to the infection.
Pharmacokinetics:
Potassium iodide is administered orally. It demonstrates significant extracellular distribution, with most of the drug accumulating in the thyroid gland. Potassium iodide distributes into breast milk and crosses the placenta in amounts sufficient enough to cause fetal harm (see Contraindications). Therapeutic effects from KI usually are observed within 24 hours after administration, with maximum effectiveness occurring after 10-15 days of therapy. Potassium iodide is excreted renally.
-Route-Specific Pharmacokinetics
Oral Route
Potassium iodide is absorbed from the GI tract as iodinated amino acids.