OLINVYK

Oliceridine 1mg/1mL, Solution for injection

Cannabis

· Severity: Major

· Notes for Consumers: Discuss cannabis use with your care team. The effects of your medication may be altered if used with cannabis. Call emergency services right away if you experience slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, or trouble staying awake.

· Notes for Professionals: Advise patients to avoid cannabis use while taking CNS depressants due to the risk for additive CNS depression and potential for other cognitive adverse reactions.

Oliceridine 1mg/1mL, Solution for injection

Grapefruit juice

· Severity: Moderate

· Notes for Consumers: Do not take Grapefruit juice or grapefruit-containing foods and Oliceridine together without talking to your health care provider. You may feel drowsy or more tired if you drink Grapefruit Juice while taking Oliceridine. Do not drive or operate machinery until you know how this drug affects you. Discuss any new or worsening side effects, such as breathing problems, confusion, constipation, dizziness, trouble passing urine or change in the amount of urine, dry mouth and eyes, changes in vision, or fast heartbeat with your health care provider.

· Notes for Professionals: Monitor patients closely for respiratory depression and sedation at frequent intervals and base subsequent doses on the patient's severity of pain and response to treatment if use oliceridine and grapefruit juice; less frequent dosing of oliceridine may be required. Concomitant use of oliceridine and grapefruit juice may increase the plasma concentration of oliceridine, resulting in increased or prolonged opioid effects; these effects may be more pronounced with grapefruit juice as it can inhibit multiple CYP enzymes. If grapefruit juice is discontinued, consider increasing the oliceridine dose until stable drug effects are achieved and monitor for evidence of opioid withdrawal. Oliceridine is a CYP3A4 and CYP2D6 substrate and grapefruit juice is a strong CYP3A4 inhibitor and moderate CYP2D6 inhibitor.

Oliceridine 1mg/1mL, Solution for injection

Alcohol

· Severity: Major

· Notes for Consumers: Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication can cause serious side effects, such as central nervous system (CNS) depression, and can increase the risk of an opioid overdose. Call emergency services right away if you experience symptoms of CNS depression: slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, trouble staying awake. Talk to your care team about naloxone, a medication for the emergency treatment of opioid overdose.

· Notes for Professionals: Advise patients to avoid alcohol consumption while taking opioids. Alcohol consumption may result in additive CNS depression and may increase the risk for opioid overdose. Consider the patient's use of alcohol when prescribing opioid medications. If the patient is unlikely to be compliant with avoiding alcohol, consider prescribing naloxone especially if additional risk factors for opioid overdose are present.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>