NOURIANZ

Istradefylline 20mg, Oral tablet

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not take Grapefruit juice or grapefruit-containing foods together with Istradefylline without talking with your health care provider. Side effects of Istradefylline may get worse. Report any new or worsening side effects such as uncontrolled or sudden movements, abnormal thinking or behavior, hallucinations, dizziness, constipation, nausea, or trouble sleeping to your doctor or healthcare professional.

· Notes for Professionals: It may be advisable for patients to avoid grapefruit juice or grapefruit-containing foods while taking istradefylline as istradefylline exposure and adverse effects may increase. Grapefruit juice is a strong CYP3A4 inhibitor. Istradefylline exposure was increased by 2.5-fold when administered with a strong inhibitor in a drug interaction study.

Istradefylline 20mg, Oral tablet

Tobacco

· Severity: Major

· Notes for Consumers: Do not smoke or use tobacco products while taking this medication. When used together, your medication may not work as well for you.

· Notes for Professionals: The initial and maximal recommended istradefylline dosage in patients who smoke 20 or more cigarettes per day (or the equivalent amount of another tobacco product) is 40 mg once daily. Tobacco smoking has been observed to decrease istradefylline overall exposure by 38% to 54% which may reduce its efficacy.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>