MARQIBO

Sodium Phosphate, Dibasic 14.2mg/1mL, Solution for injection

Caffeine-containing Foods/Beverages

· Severity: Major

· Notes for Consumers: Limit excessive Caffeine intake (examples: coffee, teas, colas, chocolate and some herbal supplements) while taking Sympathomimetics and avoid medicines containing additional Caffeine whenever possible. Examples of Sympathomimetics include stimulants or weight loss drugs like Amphetamine, Adderall, Dexedrine, Fastin, and Tenuate. Sympathomimetics also include some cough and cold products containing Pseudoephedrine (example Sudafed), Phenylephrine, or Phenylpropanolamine (PPA) and also herbal weight loss products containing ephedra or Ma huang. Taking a high amount of Caffeine with the listed drugs can increase the risk of nausea, nervousness, palpitations, problems with sleep, rapid heartbeat, or other side effects.

· Notes for Professionals: Sodium phosphates should be used with caution in patients using concomitant medications that lower the seizure threshold like psychostimulants.

Vincristine Sulfate 1mg/1mL, Solution for injection

Grapefruit juice

· Severity: Major

· Notes for Consumers: Although an interaction is possible, these drugs are sometimes used together. Side effects from Vinca Alkaloids (drugs to treat cancer such as Vinblastine, Vincristine, Vinorelbine) may get worse if you take Grapefruit Juice. Discuss any new or worsening side effects, especially severe or persistent constipation or tingling in the fingers or toes with your health care provider.

· Notes for Professionals: Grapefruit juice inhibits CYP3A4 and P-glycoprotein (P-gp); vincristine is both a CYP3A and P-gp substrate. Coadministration could increase exposure to vincristine; monitor patients for increased side effects if these drugs are given together.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>