KISQALI

Ribociclib 200mg, Oral tablet

Cannabis

· Severity: Major

· Notes for Consumers: Discuss cannabis use with your care team. The effects of cannabis may be altered if used with your medication. Call emergency services right away if you experience slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, or trouble staying awake.

· Notes for Professionals: Advise patients to avoid cannabis use during ribociclib treatment. Concomitant use may alter the exposure of some cannabinoids and increase the risk for adverse reactions. The cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are CYP3A substrates and ribociclib is a strong CYP3A inhibitor. Concomitant use of a cannabinoid product containing THC and CBD at an approximate 1:1 ratio with another strong CYP3A inhibitor increased THC, 11-OH-THC, and CBD peak exposures by 1.3-, 3-, and 1.9-fold respectively.

Ribociclib 200mg, Oral tablet

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not take ribociclib with grapefruit or grapefruit juice. Taking these together may increase ribociclib levels and ribociclib side effects.

· Notes for Professionals: Avoid the concomitant use of ribociclib and grapefruit or grapefruit juice; the systemic exposure of ribociclib may be increased resulting in an increase in ribociclib-related adverse reactions. Ribociclib is a CYP3A4 substrate and grapefruit is a strong CYP3A inhibitor. Coadministration with another strong CYP3A4 inhibitor increased the ribociclib AUC and Cmax values by 3.2-fold and 1.7-fold, respectively, in healthy volunteers.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>