DELSTRIGO

Doravirine 100mg, Lamivudine 300mg, Tenofovir Disoproxil Fumarate 300mg, Oral tablet

Grapefruit juice

· Severity: Mild

· Notes for Consumers: Grapefruit and grapefruit juice can increase the amount of Doravirine in your blood and increase the risk of side effects. Talk to your doctor or healthcare professional before eating grapefruit or drinking grapefruit juice while taking Doravirine. Report any new or worsening side effects including nausea, diarrhea, stomach pain, dizziness, headache, tiredness, or abnormal dreams.

· Notes for Professionals: Instruct patients that consuming grapefruit or grapefruit juice while taking doravirine may result in increased doravirine plasma concentrations. Doravirine is a CYP3A4 substrate; grapefruit is a strong inhibitor. In drug interaction studies, concurrent use of strong CYP3A4 inhibitors increased doravirine exposure by more than 3-fold; however, this increase was not considered clinically significant.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>