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LONAFARNIB (loe na far nib) treats genetic conditions that cause rapid aging, such as progeria. It works by reducing the buildup of proteins in the body that speed up aging. This reduces or delays symptoms, such as heart problems.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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Take this medication by mouth with water. Take it with food. Take it as directed on the prescription label at the same time every day. Do not cut, crush, or chew this medication. Swallow the capsules whole. You may open the capsule and put the contents in 5 to 10 mL of Ora Blend SF, Ora-Plus, orange juice, or 1 to 2 teaspoons of applesauce. Do not take with juice that contains grapefruit or Seville oranges. Seville oranges may also be called bitter or sour oranges. Swallow the medication mixture within 10 minutes of mixing. Do not chew the medication or applesauce. Keep taking it unless your care team tells you to stop.
Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as 12 months for selected conditions, precautions do apply.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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This medication has many interactions. Talk to your care team if you have questions.
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.
This medication may increase your risk of getting an infection. Call your care team for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.
Your vision may be tested before and during use of this medication. Tell your care team right away if you have any change in your eyesight.
Talk to your care team if you may be pregnant. This medication can cause serious birth defects if taken during pregnancy. A reliable form of contraception is recommended while taking this medication. Talk to your care team about reliable forms of contraception.
This medication may cause infertility. Talk to your care team if you are concerned about your fertility.
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If you miss a dose, take it as soon you can up to 8 hours before your next scheduled dose. If it is less than 8 hours before your next dose, take only that dose. Do not take double or extra doses.
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Side effects that you should report to your care team as soon as possible:
-Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
-Blurry vision, vision loss, seeing wavy or bent objects or blind spots with dark, light, or flashing spots
-High calcium level—increased thirst or amount of urine, nausea, vomiting, confusion, unusual weakness or fatigue, bone pain
-High potassium level—muscle weakness, fast or irregular heartbeat
-Infection—fever, chills, cough, or sore throat
-Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
-Low potassium level—muscle pain or cramps, unusual weakness or fatigue, fast or irregular heartbeat, constipation
-Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing
-Low sodium level—muscle weakness, fatigue, dizziness, headache, confusion
-Unusual bruising or bleeding
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
-Cough
-Diarrhea
-Headache
-Muscle pain
-Nausea
-Vomiting
-Weight loss
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F).
To get rid of medications that are no longer needed or have expired:
-Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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