ELEXACAFTOR; TEZACAFTOR; IVACAFTOR (el EX a KAF tor; TEZ a KAF tor; EYE va KAF tor) treats cystic fibrosis (CF). It works by helping your body balance the level of salt and water in your lungs. This prevents the buildup of mucus and reduces the symptoms of CF.

TRIKAFTA Lifestyle Interactions

  • Elexacaftor 100mg, Tezacaftor 50mg, Ivacaftor 75mg, Oral tablet

    • Interaction: Grapefruit juice
    • Severity: Major
    • Notes for Consumers: Do not drink grapefruit juice or eat grapefruit while taking this medication. Grapefruit may alter the effects of your medication. Serious side effects may occur. Contact your care team right away if you experience new or worsening side effects.
    • Notes for Professionals: Advise patients to avoid grapefruit and grapefruit juice during elexacaftor; tezacaftor; ivacaftor treatment due to the risk for increased elexacaftor; tezacaftor; ivacaftor exposure and adverse reactions. Elexacaftor, tezacaftor, and ivacaftor are CYP3A substrates and grapefruit juice is a CYP3A inhibitor.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.