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ESKETAMINE (es KET a meen) treats depression. It is prescribed when other antidepressant medications have not worked.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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This medication is for use in the nose. You will take it yourself under the supervision of your care team in a healthcare setting. Your care team will show you how to use the nasal spray device, how much to take, and when to take it. During and after each treatment, you will be checked by your care team who will decide when you can go home. You will need to plan for a caregiver or family member to drive you home each time after taking the medication. Do not drive or perform other tasks that require complete mental alertness until the day following your treatment after a restful sleep. Because this medication can cause nausea and vomiting, you should not eat for at least 2 hours before taking this medication or drink liquids for at least 30 minutes before taking this medication. If you take a nasal corticosteroid or nasal decongestant, take these medications at least 1 hour before your treatment. Do not stop your treatment except on your care team's advice.
A special MedGuide will be given to you by the pharmacist with each prescription. Be sure to read this information carefully each time.
Talk to your care team about the use of this medication in children. This medication is not approved for use in children.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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-Alcohol
-Benzodiazepines, such as alprazolam, diazepam, lorazepam
-Certain antihistamines
-Certain medications for anxiety or sleep
-Certain medications for depression, such as amitriptyline or trazodone
-Certain medications for seizures, such as phenobarbital or primidone
-Ketamine
-MAOIs, such as Marplan, Nardil, and Parnate
-Medications that cause drowsiness before a procedure, such as propofol
-Medications that help you fall asleep
-Medications that relax muscles
-Opioids for pain or cough
-Phenothiazines, such as chlorpromazine, prochlorperazine, thioridazine
-Stimulant medications for ADHD, weight loss, or staying awake
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Your condition will be monitored carefully while you are receiving this medication. Tell your care team if your symptoms do not start to get better or if they get worse.
Your care team will monitor you for serious side effects for at least 2 hours after taking this medication. Tell your care team right away if you feel like you cannot stay awake or if you feel like you are going to pass out.
This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.
This medication has a risk of abuse and dependence. Your care team will check you for this while you take this medication.
Talk to your care team if you may be pregnant. Serious birth defects can occur if you take this medication during pregnancy.
Do not breastfeed while taking this medication.
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Keep appointments for follow-up doses. It is important not to miss your dose. Call your care team if you are unable to keep an appointment.
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Side effects that you should report to your care team as soon as possible:
-Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
-CNS depression—slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, trouble staying awake
-Feeling disconnected from your thoughts, feelings, and surroundings
-Increase in blood pressure
-Thoughts of suicide or self-harm, worsening mood, feelings of depression
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
-Anxiety, nervousness
-Dizziness
-Drowsiness
-Extreme feeling of happiness or joy, intense excitement
-Nausea
-Numbness, decrease in sense of touch or sensation
-Vomiting
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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This medication is given in a hospital or clinic and will not be stored at home.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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