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TOLVAPTAN (tol VAP tan) treats low sodium levels in your body. It works by helping your kidneys remove more fluid from your blood through the urine without losing too much sodium. This helps your body maintain the right amount of sodium it needs.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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Take this medication by mouth with water. Take it as directed on the prescription label at the same time every day. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop.
Do not take this medication with grapefruit juice.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your care team about the use of this medication in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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Do not take this medication with any of the following:
-Adagrasib
-Ceritinib
-Certain antibiotics, such as chloramphenicol, clarithromycin, dalfopristin; quinupristin, telithromycin
-Certain antivirals for HIV or hepatitis
-Certain medications for fungal infection, such as ketoconazole, itraconazole, posaconazole, voriconazole
-Idelalisib
-Levoketoconazole
-Lonafarnib
-Mifepristone
-Nefazodone
-Ribociclib
-Tucatinib
This medication may also interact with the following:
-Certain medications for blood pressure, heart disease, irregular heartbeat
-Desmopressin
-Digoxin
-Diuretics
-Fluconazole
-Grapefruit juice
-Hypertonic saline
-Rifampin
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.
Check with your care team if you have severe diarrhea, nausea, and vomiting, or if you sweat a lot. The loss of too much body fluid may make it dangerous for you to take this medication.
You may need blood work done while you are taking this medication.
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If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
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Side effects that you should report to your care team as soon as possible:
-Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
-Confusion or trouble speaking, unusual weakness or fatigue, pain or trouble swallowing, loss of balance or coordination, seizures
-Dehydration—increased thirst, dry mouth, feeling faint or lightheaded, headache, dark yellow or brown urine
-High blood sugar (hyperglycemia)—increased thirst or amount of urine, unusual weakness or fatigue, blurry vision
-High potassium level—muscle weakness, fast or irregular heartbeat
-Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
-Constipation
-Dry mouth
-Increase in amount of urine
-Increased thirst
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
-Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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