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APOMORPHINE (a poe MOR feen) treats the symptoms of Parkinson disease. It works by acting like dopamine, a substance in your body that helps manage movements and coordination. This reduces the symptoms of Parkinson, such as body stiffness and tremors.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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This medication is infused under the skin. You will be taught how to prepare and give it. Keep taking it unless your care team tells you to stop. Stopping it too quickly can cause serious side effects. It can also make your condition worse.
This medication comes with INSTRUCTIONS FOR USE. Ask your pharmacist for directions on how to use this medication. Read the information carefully. Talk to your pharmacist or care team if you have questions.
It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or care team to get one.
Talk to your care team about the use of this medication in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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Do not take this medication with any of the following:
-Cisapride
-Dronedarone
-Ketoconazole
-Levoketoconazole
-Pimozide
-Some medications for nausea or vomiting, such as dolasetron, granisetron, ondansetron, palonosetron
-Thioridazine
This medication may also interact with the following:
-Alcohol
-Benzodiazepines, such as alprazolam, diazepam, lorazepam
-Droperidol
-Metoclopramide
-Nitroglycerin
-Opioids
-Other medications that cause heart rhythm changes
-Phenothiazines, such as chlorpromazine or prochlorperazine
-Some medications for anxiety or sleep
-Some medications for blood pressure
-Some medications for mental health conditions, such as haloperidol or risperidone
-Tetrabenazine
-Thiothixene
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.
This medication may cause nausea and vomiting, which can be severe. Your care team may give you medication to decrease your symptoms. Do not treat yourself. Not all medications for nausea and vomiting can be used with this medication. Your care team can help you find the option that is right for you.
This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.
When taking this medication, you may fall asleep without notice. You may be doing activities, such as driving a car, talking, or eating. You may not feel drowsy before it happens. Contact your care team right away if this happens to you.
Taking nitroglycerin with this medication can cause a sudden drop in blood pressure. This can cause dizziness and fainting. If you need to take nitroglycerin under the tongue while on this medication, lie down first. Then, take the medication. Keep lying down for at least 45 minutes after you take it.
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Talk to your care team about what to do if you are not able to use this infusion. You may need an extra dose if the infusion has been stopped for 1 hour or more.
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Side effects that you should report to your care team as soon as possible:
-Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
-Chest pain (angina)—pain, pressure, or tightness in the chest, neck, back, or arms
-Falling asleep during daily activities
-Hallucinations
-Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
-Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
-Hemolytic anemia—unusual weakness or fatigue, dizziness, headache, trouble breathing, dark urine, yellowing skin or eyes
-Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision
-New or worsening uncontrolled and repetitive movements of the face, mouth, or upper body
-Prolonged or painful erection
-Unusual changes in behavior
-Urges to engage in impulsive behaviors such as gambling, binge eating, sexual activity, or shopping in ways that are unusual for you
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
-Dizziness
-Drowsiness
-Headache
-Nausea
-Pain, redness, or irritation at injection site
-Trouble sleeping
-Vomiting
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
-Take the medication to a take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, ask your pharmacist or care team how to get rid of it safely.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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