MEXILETINE HCL

Mexiletine Hydrochloride 150mg, Oral capsule

Cannabis

· Severity: Major

· Notes for Consumers: Discuss cannabis use with your care team. The effects of your medication may be altered if used with cannabis.

· Notes for Professionals: Advise patients to avoid cannabis use during mexiletine treatment due to decreased exposure of mexiletine which may alter its efficacy. Cannabis use induces CYP1A2 and mexiletine is a CYP1A2 substrate. The induction potential of cannabis is greatest with chronic inhalation. Other routes of administration or sporadic use may have less of an effect.

Mexiletine Hydrochloride 150mg, Oral capsule

Tobacco

· Severity: Major

· Notes for Consumers: Do not smoke or use tobacco products while taking this medication. When used together, your medication may not work as well for you.

· Notes for Professionals: Advise patients to avoid tobacco products while receiving mexiletine. Tobacco smoking has been noted to significantly enhance the rate of elimination of mexiletine, possibly leading to subtherapeutic clinical effects. Mexiletine is a CYP1A2 substrate and smoking tobacco induces CYP1A2.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>