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PEGZILARGINASE (PEG zil AR ji nase) treats arginase 1 deficiency (ARG1-D). It works by replacing an enzyme normally made by your body, which reduces the levels of arginine in the blood. This may help reduce symptoms of ARG1-D.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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This medication is injected into a vein or under the skin. If it is injected into a vein, it is given by your care team in a hospital or clinic setting. If it is injected under the skin, it may be given at home.
If you get this medication at home, you will be taught how to prepare and give it. Take it as directed on the prescription label. Keep taking it unless your care team tells you to stop.
It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or care team to get one.
Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as 2 years for selected conditions, precautions do apply.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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Interactions are not expected.
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.
You may need blood work done while you are taking this medication.
This medication can cause serious allergic reactions. To reduce the risk, your care team may give you other medications to take before receiving this one. Follow the directions from your care team.
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If you get this medication at the hospital or clinic: It is important not to miss your dose. Call your care team if you are not able to keep your appointment.
If you give yourself this medication at home: It is important not to miss your dose. Talk to your care team about what to do if you miss a dose.
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Side effects that you should report to your care team as soon as possible:
-Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
-Constipation
-Dizziness
-Fever
-Pain, redness, or irritation at injection site
-Sore throat
-Vomiting
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Keep out of the reach of children and pets.
This medication is usually given in a hospital or clinic. If you take this medication at home, your care team will tell you how to store it. Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
-Take the medication to a take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, ask your pharmacist or care team how to get rid of it safely.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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