• Image of Sporanox medication Image of Sporanox medication
    • ITRACONAZOLE (Generic for SPORANOX)

    • QTY 60
    • 100 MG
    • Capsule
    • Near  77381

ITRACONAZOLE (i tra KO na zole) treats fungal infections. It belongs to a group of medications called antifungals. It will not treat colds, the flu, or infections caused by bacteria or viruses.


ITRACONAZOLE (Generic for SPORANOX) Lifestyle Interactions

  • Itraconazole 100mg, Oral capsule

    Interaction: Cannabis
    Severity: Major
    Notes for Consumers: Discuss cannabis use with your care team. The effects of cannabis may be altered if used with your medication. Call emergency services right away if you experience slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, or trouble staying awake.
    Notes for Professionals: Advise patients to avoid cannabis use during itraconazole treatment. Concomitant use may alter the exposure of some cannabinoids and increase the risk for adverse reactions. The cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are CYP3A substrates and itraconazole is a strong CYP3A inhibitor. Concomitant use of a cannabinoid product containing THC and CBD at an approximate 1:1 ratio with another strong CYP3A inhibitor increased THC, 11-OH-THC, and CBD peak exposures by 1.3-, 3-, and 1.9-fold respectively.
  • Itraconazole 100mg, Oral capsule

    Interaction: Food
    Severity: Moderate
    Notes for Consumers: Itraconazole oral solution should be taken without food, while Itraconazole capsules should be taken with a full meal.
    Notes for Professionals: Oral bioavailability of itraconazole from the capsules is increased if administered with a meal or cola beverage. Administration with orange juice should be avoided.
  • Itraconazole 100mg, Oral capsule

    Interaction: Grapefruit juice
    Severity: Mild
    Notes for Consumers: It is best not to change your usual intake of grapefruit juice while taking Itraconazole. Grapefruit juice may decrease the actions of Itraconazole.
    Notes for Professionals: Grapefruit juice reduced the mean peak itraconazole concentration by 35 percent when itraconazole capsules were administered with grapefruit juice in healthy volunteers; the AUC was reduced by an average of 43 percent compared to administration with water. Conversely, another study reported that grapefruit juice did not significantly affect the bioavailability of itraconazole capsules.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.