Nutritional Supplement

Manganese

  • Negative Interactions

    12

    • Manganese

      Ciprofloxacin

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Ciprofloxacin
      Manganese
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.

    • Manganese

      Ciprofloxacin in D5W

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Ciprofloxacin in D5W
      Manganese
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.

    • Manganese

      Delafloxacin

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Delafloxacin
      Manganese
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.

    • Manganese

      Gatifloxacin

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Gatifloxacin
      Manganese
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.

    • Manganese

      Gatifloxacin in D5W

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Gatifloxacin in D5W
      Manganese
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.

    • Manganese

      Gemifloxacin

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Gemifloxacin
      Manganese
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.

    • Manganese

      Levofloxacin

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Levofloxacin
      Manganese
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.

    • Manganese

      Levofloxacin in D5W

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Levofloxacin in D5W
      Manganese
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.

    • Manganese

      Moxifloxacin

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Moxifloxacin
      Manganese
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.

    • Manganese

      Moxifloxacin in Saline

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Moxifloxacin in Saline
      Manganese
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.

    • Manganese

      Norfloxacin

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Norfloxacin
      Manganese
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.

    • Manganese

      Ofloxacin

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Ofloxacin
      Manganese
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.

  • Supportive Interactions

    20

    • Manganese

      Desogestrel-Ethinyl Estradiol

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Desogestrel-Ethinyl Estradiol
      Manganese
      ×
      1. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

    • Manganese

      Drospirenone-Estetrol

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Drospirenone-Estetrol
      Manganese
      ×
      1. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

    • Manganese

      Drospirenone-Ethinyl Estradiol

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Drospirenone-Ethinyl Estradiol
      Manganese
      ×
      1. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

    • Manganese

      Drospir-Eth Estra-Levomefol Ca

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Drospir-Eth Estra-Levomefol Ca
      Manganese
      ×
      1. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

    • Manganese

      Estradiol Valerate-Dienogest

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Estradiol Valerate-Dienogest
      Manganese
      ×
      1. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

    • Manganese

      Ethinyl Estradiol and Norgestrel

      Replenish Depleted Nutrients

      A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1, B2, B3, B12, C, and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A. Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Ethinyl Estradiol and Norgestrel
      Manganese
      ×
      1. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210-1 [review].
      2. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561-4.
      3. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197-8.
      4. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711-5.
      5. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

    • Manganese

      Ethynodiol Diac-Eth Estradiol

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Ethynodiol Diac-Eth Estradiol
      Manganese
      ×
      1. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

    • Manganese

      Ethynodiol-Ethinyl Estradiol

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Ethynodiol-Ethinyl Estradiol
      Manganese
      ×
      1. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

    • Manganese

      Levonorgest-Eth.Estradiol-Iron

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Levonorgest-Eth.Estradiol-Iron
      Manganese
      ×
      1. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

    • Manganese

      Levonorgestrel-Ethinyl Estrad

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Levonorgestrel-Ethinyl Estrad
      Manganese
      ×
      1. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

    • Manganese

      Levonorg-Eth Estrad Triphasic

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Levonorg-Eth Estrad Triphasic
      Manganese
      ×
      1. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

    • Manganese

      L-Norgest&E Estradiol-E Estrad

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      L-Norgest&E Estradiol-E Estrad
      Manganese
      ×
      1. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

    • Manganese

      Mestranol and Norethindrone

      Replenish Depleted Nutrients

      A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1, B2, B3, B12, C, and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A. Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Mestranol and Norethindrone
      Manganese
      ×
      1. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210-1 [review].
      2. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561-4.
      3. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197-8.
      4. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711-5.
      5. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

    • Manganese

      Noreth-Ethinyl Estradiol-Iron

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Noreth-Ethinyl Estradiol-Iron
      Manganese
      ×
      1. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

    • Manganese

      Norethindrn A-E Estradiol-Iron

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Norethindrn A-E Estradiol-Iron
      Manganese
      ×
      1. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

    • Manganese

      Norethindrone Ac-Eth Estradiol

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Norethindrone Ac-Eth Estradiol
      Manganese
      ×
      1. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

    • Manganese

      Norethindrone-Ethin Estradiol

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Norethindrone-Ethin Estradiol
      Manganese
      ×
      1. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

    • Manganese

      Norethin-Eth Estrad Biphasic

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Norethin-Eth Estrad Biphasic
      Manganese
      ×
      1. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

    • Manganese

      Norethin-Eth Estrad Triphasic

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Norethin-Eth Estrad Triphasic
      Manganese
      ×
      1. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

    • Manganese

      Norgestimate-Ethinyl Estradiol

      Replenish Depleted Nutrients

      A review of literature suggests that women who use OCs may experience decreased vitamin B1, B2, B3, B12, C, and zinc levels. OC use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A. OCs may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Norgestimate-Ethinyl Estradiol
      Manganese
      ×
      1. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210-1 [review].
      2. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561-4.
      3. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197-8.
      4. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711-5.
      5. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

  • Explanation Required

    5

    • Manganese

      Desogestrel-Ethinyl Estradiol

      Needs Explanation

      A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1, B2, B3, B12, C, and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A. Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Desogestrel-Ethinyl Estradiol
      Manganese
      ×
      1. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210-1 [review].
      2. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561-4.
      3. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197-8.
      4. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711-5.
      5. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

    • Manganese

      Ethinyl Estradiol and Levonorgestrel

      Needs Explanation
      A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1, B2, B3, B12, C, and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A. Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.
      Ethinyl Estradiol and Levonorgestrel
      Manganese
      ×
      1. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210-1 [review].
      2. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561-4.
      3. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197-8.
      4. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

    • Manganese

      Ethinyl Estradiol and Norethindrone

      Needs Explanation

      A review of literature suggests that women who use OCs may experience decreased vitamin B1, B2, B3, B12, C, and zinc levels. OC use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A. OCs may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Ethinyl Estradiol and Norethindrone
      Manganese
      ×
      1. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210-1 [review].
      2. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561-4.
      3. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197-8.
      4. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711-5.
      5. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

    • Manganese

      Ethinyl Estradiol and Norgestimate

      Needs Explanation
      Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A. Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

       

      Ethinyl Estradiol and Norgestimate
      Manganese
      ×
      1. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210-1 [review].
      2. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561-4.
      3. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711-5.
      4. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

    • Manganese

      Levonorgestrel-Ethinyl Estrad

      Needs Explanation

      A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1, B2, B3, B12, C, and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A. Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Levonorgestrel-Ethinyl Estrad
      Manganese
      ×
      1. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210-1 [review].
      2. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561-4.
      3. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197-8.
      4. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711-5.
      5. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

References

1. Li L, Yang X. The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions. Oxid Med Cell Longev 2018;2018:7580707.

2. Shan Z, Chen S, Sun T, et al. U-Shaped Association between Plasma Manganese Levels and Type 2 Diabetes. Environ Health Perspect 2016;124:1876–81.

3. Burlet E, Jain S. Manganese supplementation increases adiponectin and lowers ICAM-1 and creatinine blood levels in Zucker type 2 diabetic rats, and downregulates ICAM-1 by upregulating adiponectin multimerization protein (DsbA-L) in endothelial cells. Mol Cell Biochem 2017;429:1–10.

4. Burlet E, Jain S. Manganese supplementation reduces high glucose-induced monocyte adhesion to endothelial cells and endothelial dysfunction in Zucker diabetic fatty rats. J Biol Chem 2013;288:6409–16.

5. Anderson RA et al. Chromium supplementation of humans with hypoglycemia. Fed Proc 1984;43:471.

6. Stebbing JB et al. Reactive hypoglycemia and magnesium. Magnesium Bull 1982;2:131-4.

7. Shansky A. Vitamin B3 in the alleviation of hypoglycemia. Drug Cosm Ind 1981;129(4):68-69,104-5.

8. Gaby AR, Wright JV. Nutritional regulation of blood glucose. J Advancement Med 1991;4:57-71.

9. Mohammedi K, Bellili-Munoz N, Driss F, et al. Manganese superoxide dismutase (SOD2) polymorphisms, plasma advanced oxidation protein products (AOPP) concentration and risk of kidney complications in subjects with type 1 diabetes. PLoS One 2014;9:e96916.

10. Mollsten A, Jorsal A, Lajer M, et al. The V16A polymorphism in SOD2 is associated with increased risk of diabetic nephropathy and cardiovascular disease in type 1 diabetes. Diabetologia 2009;52:2590–3.

11. Kangas-Kontio T, Vavuli S, Kakko S, et al. Polymorphism of the manganese superoxide dismutase gene but not of vascular endothelial growth factor gene is a risk factor for diabetic retinopathy. Br J Ophthalmol 2009;93:1401–6.

12. Forte G, Bocca B, Peruzzu A, et al. Blood metals concentration in type 1 and type 2 diabetics. Biol Trace Elem Res 2013;156:79–90.

13. Lee S, Jouihan H, Cooksey R, et al. Manganese supplementation protects against diet-induced diabetes in wild type mice by enhancing insulin secretion. Endocrinology 2013;154:1029–38.

14. Manganese-Induced Hypoglycemia. JAMA 1963;183:227.

15. Sandstead HH. Understanding zinc: Recent observations and interpretations. J Lab Clin Med 1994;124:322-7.

16. Tenaud I, Sainte-Marie I, Jumbou O, et al. In vitro modulation of keratinocyte wound healing integrins by zinc, copper and manganese. Br J Dermatol 1999;140:26-34.

17. Pereira CE, Felcman J. Correlation between five minerals and the healing effect of Brazilian medicinal plants. Biol Trace Elem Res 1998;65:251-9.

18. Carlisle EM. Silicon as an essential trace element in animal nutrition. Ciba Found Symp 1986;121:123-39.

19. Leach RM. Role of manganese in mucopolysaccharide metabolism. Fed Proc 1971;30:991.

20. Gold M. Basketball bones. Science 1980;80:101-2.

21. Raloff J. Reasons for boning up on manganese. Science News 1986;Sep 27:199 [review].

22. Strause L, Saltman P, Smith KT, et al. Spinal bone loss in postmenopausal women supplemented with calcium and trace minerals. J Nutr 1994;124:1060-4.

23. Abraham GE, Grewal H. A total dietary program emphasizing magnesium instead of calcium. J Reprod Med 1990;35:503-7.

24. Aston B. Manganese and man. J Orthomolec Psychiatry 1980;9:237-49.

25. National Research Council. Recommended Dietary Allowances. 10th ed. Washington, DC: National Academy Press, 1989.

26. Raloff J. Reasons for boning up on manganese. Science News 1986;Sep 27:199 [review].

27. Nagatomo S, Umehara F, Hanada K, et al. Manganese intoxication during total parenteral nutrition: report of two cases and review of the literature. J Neurol Sci 1999;162:102-5.

28. Ejima A, Imamura T, Nakamura S, et al. Manganese intoxication during total parenteral nutrition. Lancet 1992;339:426 [letter].

29. Fell JM, Reynolds AP, Meadows N, et al. Manganese toxicity in children receiving long-term parenteral nutrition. Lancet 1996;347:1218-21.

30. Ferraz HB, Bertolucci PH, Pereira JS, et al. Chronic exposure to the fungicide maneb may produce symptoms and signs of CNS manganese intoxication. Neurology 1988;38:550-3.

31. Krieger D, Krieger S, Jansen O, et al. Manganese and chronic hepatic encephalopathy. Lancet 1995;346:270-4.

32. Staunton M, Phelan DM. Manganese toxicity in a patient with cholestasis receiving total parenteral nutrition. Anaesthesia 1995;50:665.

33. Rubenstein AH, Levin NW, Elliott GA. Hypoglycaemia induced by manganese. Nature (London) 1962;194:188-9.

Copyright © 2024 TraceGains, Inc. All rights reserved.

Learn more about TraceGains, the company.

The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.

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