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Nutritional Supplement

Goldenseal

  • Negative Interactions

    1
    • Goldenseal

      Tetracycline

      Potential Negative Interaction

      Berberine, a chemical extracted from goldenseal (Hydrastis canadensis),barberry (Berberis vulgaris), and Oregon grape (Berberis aquifolium), has been shown to have antibacterial activity. One double-blind study found that giving 100 mg of berberine at the same time as 500 mg of tetracycline four times daily led to a reduction of the efficacy of tetracycline in people with cholera. Berberine may have decreased the absorption of tetracycline in this study. Another double-blind trial did not find that berberine interfered with tetracycline in cholera patients. Until more studies are completed to clarify this issue, berberine-containing herbs should not be taken simultaneously with tetracycline.

      Tetracycline
      Goldenseal
      ×
      1. Khin-Maung-U, Myo-Khin, Nyunt-Nyunt-Wai, et al. Clinical trial of berberine in acute watery diarrhoea. Br Med J 1985;291:1601-5.
      2. Rabbani GH, Butler T, Knight J, et al. Randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic Escherichia coli and Vibrio cholerae. J Infect Dis 1987;155:979-84.
  • Explanation Required

    1
    • Goldenseal

      Doxycycline

      Needs Explanation

      Berberine is a chemical extracted from goldenseal (Hydrastis canadensis),barberry (Berberis vulgaris), and Oregon grape (Berberis aquifolium), which has antibacterial activity. However, one double-blind study found that 100 mg berberine given with tetracycline (a drug closely related to doxycycline) reduced the efficacy of tetracycline in people with cholera. In that trial, berberine may have decreased tetracycline absorption. Another double-blind trial found that berberine neither improved nor interfered with tetracycline effectiveness in cholera patients. Therefore, it remains unclear whether a significant interaction between berberine-containing herbs and doxycycline and related drugs exists.

      Doxycycline
      Goldenseal
      ×
      1. Khin-Maung-U, Myo-Khin, Nyunt-Nyunt-Wai, et al. Clinical trial of berberine in acute watery diarrhoea. Br Med J 1985;291:1601-5.
      2. Rabbani GH, Butler T, Knight J, et al. Randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic Escherichia coli and Vibrio cholerae. J Infect Dis 1987;155:979-84.

References

1. Foster S, Tyler VE. Tyler's Honest Herbal. New York: Haworth Herbal Press, 1999, 195-7.

2. Hahn FE, Ciak J. Berberine. Antibiotics 1976;3:577-88 [review].

3. Kamat SA. Clinical trial with berberine hydrochloride for the control of diarrhea in acute gastroenteritis. J Assoc Physicians India 1967;15:525-9.

4. Murray, MT. The Healing Power of Herbs. Rocklin, CA: Prima Publishing, 1995, 162-72.

5. Bradley PR, ed. British Herbal Compendium, Vol. 1. Bournemouth, Dorset, UK: British Herbal Medicine Association, 1992, 119-20.

6. Beuscher N, Kopanski L. Stimulation of immunity by the contents of Baptisia tinctoria. Planta Med 1985;5:381-4.

7. Blumenthal M, Goldberg A, Brinckmann J. Herbal Medicine: Expanded Commission E Monographs.Newton, MA: Integrative Medicine Communications, 1999.

8. Murray MT. The Healing Power of Herbs. Rocklin, CA: Prima Publishing, 1995.

9. Gupte S. Use of berberine in treatment of giardiasis. Am J Dis Child 1975;129:866.

10. Choudhry VP, Sabir M, Bhide VN. Berberine in giardiasis. Indian Pediatr 1972;9:143-6.

11. Kaneda Y, Torii M, Tanaka T, Aikawa M. In vitro effects of berberine sulphate on the growth and structure of Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis. Ann Trop Med Parasitol 1991;85:417-25.

12. Schulz V, Hänsel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. 3rd ed, Berlin: Springer, 1998, 168-73.

13. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin: American Botanical Council and Boston: Integrative Medicine Communications, 1998, 425-6.

14. Tewari JP, Srivastava MC, Bajpai JL. Pharmacologic studies of Achillea millefolium Linn. Indian J Med Sci 1994;28(8):331-6.

15. Bae EA, Han MJ, Kim NJ, Kim DH. Anti-Helicobacter pylori activity of herbal medicines. Biol Pharm Bull 1998;21(9):990-2.

16. Khin-Maung-U, Myo-Khin, Nyunt-Nyunt-Wai, et al. Clinical trial of berberine in acute watery diarrhoea. Br Med J 1985;291:1601-5.

17. Nasemann T. Kamillosan therapy in dermatology. Z Allgemeinmed 1975; 25:1105-6.

18. Blumenthal M, Goldberg A, Brinckmann J. Herbal Medicine: Expanded Commission E Monographs.Newton, MA: Integrative Medicine Communications, 1999.

19. Hahn FE, Ciak J. Berberine. Antibiotics 1976;3:577-88 [review].

20. Mahajan VM, Sharma A, Rattan A. Antimycotic activity of berberine sulphate: an alkaloid from an Indian medicinal herb. Sabouraudia 1982;20:79-81.

21. Bhakat MP. Therapeutic trial of Berberine sulphate in non-specific gastroenteritis. Indian Med J 1974;68:19-23.

22. Kamat SA. Clinical trial with berberine hydrochloride for the control of diarrhoea in acute gastroenteritis. J Assoc Physicians India 1967;15:525-9.

23. Desai AB, Shah KM, Shah DM. Berberine in the treatment of diarrhoea. Indian Pediatr 1971;8:462-5.

24. Melchart D, Linde K, Worku F, et al. Immunomodulation with echinacea—a systematic review of controlled clinical trials. Phytomedicine 1994;1:245-54 [review].

25. Hudson T. Women's Encyclopedia of Natural Medicine. Lincolnwood, IL: Keats, 1999, 54.

26. Zhang H, Wei J, Xue R, et al. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism 2010;59:285-92

27. Sun DX, Abraham SN, Beachey EH. Influence of berberine sulfate on synthesis and expression of pap fimbrial adhesin in uropathogenic Escherichia coli. Antimicrob Agents Chemother 1988;32:1274-7.

28. Hahn FE, Ciak J. Berberine. Antibiotics 1976;3:577-88 [review].

29. Mahajan VM, Sharma A, Rattan A. Antimycotic activity of berberine sulphate: an alkaloid from an Indian medicinal herb. Sabouraudia 1982;20:79-81.

30. Bhakat MP. Therapeutic trial of Berberine sulphate in non-specific gastroenteritis. Indian Med J 1974;68:19-23.

31. Kamat SA. Clinical trial with berberine hydrochloride for the control of diarrhoea in acute gastroenteritis. J Assoc Physicians India 1967;15:525-9.

32. Desai AB, Shah KM, Shah DM. Berberine in the treatment of diarrhoea. Indian Pediatr 1971;8:462-5.

33. Babbar OP, Chatwal VK, Ray IB, et al. Effect of berberine chloride eye drops on clinically positive trachoma patients. Ind J Med Res 1982;76:83-8.

34. Ellingwood F. American Materia Medica, Therapeutics and Pharmacognosy. 1919. Reprint, Sandy, OR: Eclectic Medical Publications, 1998.

35. Murray, MT. The Healing Power of Herbs. Rocklin, CA: Prima Publishing, 1995, 162-72.

36. Bannerman JE. Goldenseal in world trade: Pressures and potentials. HerbalGram 1997;41:51-2.

37. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: Pharmaceutical Press, 1996, 151-2.

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The information presented by Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2019.