Nutritional Supplement

Chaparral

Parts Used & Where Grown

Chaparral takes its name from the area in which it grows, the desert regions of the southwestern United States and northern Mexico known as the chaparral ecosystem. The leaves and stems of this ancient plant are used as medicine.

How It Works

The major lignan in chaparral, known as nordihydroguaiaretic acid (NDGA) is a potent antioxidant and was thought by some scientists to be a potential cancer treatment. In a rat study, NDGA and a leaf extract of a South American subspecies of chaparral were found to exert an antitumor effect.1 However, one report suggests that NDGA may stimulate further growth of tumors in cancer patients.2 Clinical trials, therefore, are still needed to establish whether chaparral is a safe and effective treatment for people with cancer.

Other reported effects for chaparral include anti-inflammatory properties3,4 as well as antimicrobial actions in test tubes.5 These actions have note been established in human clinical trials

References

1. Birkenfeld S, Zaltsman YA, Krispin M, et al. Antitumor effects of inhibitors of arachadonic acid cascade on experimentally induced intestinal tumors. Dis Colon Rectum 1987;30:43-6.

2. Smart CR, Hogle CR, Vogel H, et al. Clinical experience with nordihydroguaiaretic acid—”chapparel tea” [sic] in the treatment of cancer. Rocky Mtn Med J 1970;67:39-43.

3. Bokoch G, Reed P. Evidence for inhibition of leukotriene A4 synthesis by 5,8,11,14-eicosatetraynoic acid in guinea pig polymorphonuclear leukocytes. J Biol Chem 1981;256:4156.

4. Salari H, Braquet P, Borgeat P. Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets. Prostaglan Leukot Med 1984;13:53-60.

5. Calzado-Flores C, Segura-Luna JJ, Guajardo-Touche EM. Effects of chaparrin, nordihydroguaiaretic acid and their structural analogues on Entamoeba histolytica cultures. Proc West Pharmacol Soc 1995;38:105-6.

6. Kay MA. Healing with Plants in the American and Mexican West. Tucson: University of Arizona Press, 1996, 178-81.

7. Kay MA. Healing with Plants in the American and Mexican West. Tucson: University of Arizona Press, 1996, 178-81.

8. Brinker F. Larrea tridentata (D.C.) Coville (chaparral or creosote bush). Br J Phytother 1993/1994;3:10-31 [review].

9. Moore M. Medicinal Plants of the Desert and Canyon West. Santa Fe: Museum of New Mexico Press, 1989, 27-9.

10. Kay MA. Healing with Plants in the American and Mexican West. Tucson: University of Arizona Press, 1996, 178-81.

11. Kay MA. Healing with Plants in the American and Mexican West. Tucson: University of Arizona Press, 1996, 178-81.

12. Moore M. Medicinal Plants of the Desert and Canyon West. Santa Fe: Museum of New Mexico Press, 1989, 27-9.

13. Sheikh NM, Philen RM, Love LA. Chaparral-associated hepatotoxicity. Arch Int Med 1997;157:913-9.

14. Smart CR, Hogle CR, Vogel H, et al. Clinical experience with nordihydroguaiaretic acid—”chapparel tea” [sic] in the treatment of cancer. Rocky Mtn Med J 1970;67:39-43.

15. McGuffin M, Hobbs C, Upton R, Goldberg A. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, 1997, 67.

Copyright © 2024 TraceGains, Inc. All rights reserved.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.

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