Epilepsy

Health Condition

Epilepsy

The right diet is the key to managing many diseases and to improving general quality of life. For this condition, scientific research has found benefit in the following healthy eating tips.

  • Atkins Diet

    Some epileptics have become seizure-free on the Atkins diet, which is similar to the ketogenic diet but is easier to follow, as it allows more protein and has fewer calorie restrictions.
    Atkins Diet
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    The Atkins diet is similar to the ketogenic diet, in that they are both high in fat and very low in carbohydrate. The Atkins diet, however, is easier to follow than the ketogenic diet, as it allows more liberal amounts of protein and has fewer calorie restrictions. Since the Atkins diet can produce ketosis, it has the potential to benefit people with epilepsy. In a preliminary study, three of six individuals with treatment-resistant epilepsy experienced marked improvement on the Atkins diet; two of these people became seizure-free.24

  • Elimination Diet

    Work with a knowledgeable professional to find out if eliminating certain foods reduces seizure frequency.
    Elimination Diet
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    Allergic reactions to food have been reported to trigger epileptic seizures in individual cases,25,26 some of which were proven with double-blind testing.27 One report found people with epilepsy to have significantly more biochemical evidence of allergy than do non-epileptics.28 A study of children who suffered from both epilepsy and migraine headaches found that a diet low in potential food allergens reduced seizures in the majority of cases; however, children who had epilepsy alone without migraines did not respond to the diet.29 Another report confirmed that children who have epilepsy without migraines do not improve on a low-allergen diet.30 Some doctors recommend that people with epilepsy and other allergic symptoms, such as asthma or hay fever, should be checked for food allergies that may be causing seizures.27

  • Ketogenic Diet

    To help reduce seizures in children, consult a specialist trained in initiating and supervising this special diet.
    Ketogenic Diet
    ×

    The ketogenic diet was developed in the early twentieth century when few drug treatments for epilepsy were available; until recently, it had been used only when drug therapy was ineffective. The dietary approach was based on the observation that ketosis (increased blood levels of chemicals called ketones) is associated with reduction of seizures.31 Ketosis can be produced by a diet high in fat and very low in carbohydrate and protein. The ketogenic diet has been evaluated in several preliminary and a few controlled trials. According to a 1996 review, the ketogenic diet appears to be very effective in one-third to one-half of epilepsy cases in children, and partially effective in another one-third of cases.32

    Recent trials continue to support this success rate;33,34,35 one preliminary trial demonstrated a 50% reduction in seizure activity in 71% of children in a group after 45 days on the diet. There is little research on the effects of the ketogenic diet in adults, but it may be effective in those who are able to comply with the strict dietary guidelines.36,37 The diet is usually initiated by fasting under close medical supervision, often in a hospital, followed by introduction of the diet and training of the family to ensure successful maintenance.

    Possible side effects of the ketogenic diet include gastrointestinal upset, dehydration, anemia, low blood protein levels, high blood levels of fat and acidity, kidney stones, and signs of liver toxicity.38,32 Vitamin and mineral supplementation is necessary due to the many deficiencies of this unusual diet.40 The ketogenic diet should not be attempted without the supervision of a qualified healthcare professional. Practical information about the ketogenic diet is available in recent texts 41 and articles,42 as well as on the Internet.43

References

1. Schlanger S, Shinitzky M, Yam D. Diet enriched with omega-3 fatty acids alleviates convulsion symptoms in epilepsy patients. Epilepsia 2002;43:103-104.

2. Yuen AW, Sander JW, Fluegel D, et al. Omega-3 fatty acid supplementation in patients with chronic epilepsy: a randomized trial. Epilepsy Behav 2005;7:253–8.

3. DeGiorgio CM, Miller PR, Harper R, et al. Fish oil (n-3 fatty acids) in drug resistant epilepsy: a randomised placebo-controlled crossover study. J Neurol Neurosurg Psychiatry 2015;86:65–70.

4. Abdelmalik PA, Politzer N, Carlen PL. Magnesium as an effective adjunct therapy for drug resistant seizures. <em>Can J Neurol Sci</em> 2012;39:323-7.

5. Yarnell EY, Abascal K. An herbal formula for treating intractable epilepsy: a review of the literature. Alt Compl Ther 2000;6:203-6 [review].

6. Narita Y, Satowa H, Kokubu T, et al. Treatment of epileptic patients with the Chinese herbal medicine “saiko-keishi-to” (SK). IRCS Med Sci 1982;10:88-9.

7. Nagakubo S, Niwa S-I, Kumagai N, et al. Effects of TJ-960 on Sternberg's paradigm results in epileptic patients. Jpn J Psych Neur 1993;47:609-19.

8. Hollo A, Clemens Z, Kamondi A, et al. Correction of vitamin D deficiency improves seizure control in epilepsy: a pilot study. Epilepsy Behav 2012;24:131-3.

9. Mukherjee GD, Dey CD. Comparative study on the anti-epileptic action of some common phyto-products. J Exp Med Sci 1968;11:82-5.

10. Mukherjee GD, Dey CD. Clinical trial on Brahmi. J Exp Med Sci 1966;10:5-11.

11. Gibberd FB, Nicholls A, Wright MG. The influence of folic acid on the frequency of epileptic attacks. Eur J Clin Pharmacol 1981;19:57-60.

12. Guidolin L, Vignoli A, Canger R. Worsening in seizure frequency and severity in relation to folic acid administration. Eur J Neurol 1998;5:301-3.

13. Lewis DP, Van Dyke DC, Willhite LA. Phenytoin-folic acid interaction. Ann Pharmacother 1995;29:726-35 [review].

14. Berg MJ, Rivey MP, Vern BA, et al. Phenytoin and folic acid: individualized drug-drug interaction. Ther Drug Monit 1983;5:395-9.

15. Reynolds EH. Effects of folic acid on the mental state and fit frequency of drug treated epileptic patients. Lancet 1967;1:1086.

16. Eros E, Geher P, Gomor B, et al. Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy). Eur J Obstet Gynecol Reprod Biol 1998;80:75-8.

17. Ueda S, Shirakawa T, Nakazawa Y, et al. Epilepsy and folic acid. Folia Psychiatr Neurol Jpn 1977;31:327-37.

18. Fauteck J, Schmidt H, Lerchl A, et al. Melatonin in epilepsy: first results of replacement therapy and first clinical results. Biol Signals Recept 1999;8:105-10.

19. Durelli L, Mutani R. The current status of taurine in epilepsy. Clin Neuropharmacol 1983;6:37-48.

20. Bankier A, Turner M, Hopkins IJ. Pyridoxine dependent seizures—a wider clinical spectrum. Arch Dis Child 1983;58:415-8.

21. Baxter P, Griffiths P, Kelly T, et al. Pyridoxine-dependent seizures: demographic, clinical, MRI and psychometric features, and effect of dose on intelligence quotient. Develop Med Child Neurol 1996;38:998-1006.

22. Jiao FY, Gao DY, Takuma Y, et al. Randomized, controlled trial of high-dose intravenous pyridoxine in the treatment of recurrent seizures in children. Pediatr Neurol 1997;17:54-7.

23. Goutieres F, Aicardi J. Atypical presentation of pyridoxine-dependent seizures: a treatable cause of intractable epilepsy in infants. Ann Neurol 1985;17:117-20.

24. Kossoff EH, Krauss GL, McGrogan JR, Freeman JM. Efficacy of the Atkins diet as therapy for intractable epilepsy. Neurology 2003;61:1789-91.

25. Stevens H. Allergy and epilepsy. Epilepsia 1965;6:205-16 [review].

26. Campbell M. Neurologic manifestations of allergic disease. Ann Allergy 1973;31:485-98 [review].

27. Crayton JW, Stone T, Stein G. Epilepsy precipitated by food sensitivity: report of a case with double-blind placebo-controlled assessment. Clin Electroencephalogr 1981;12:192-8.

28. Cunningham AS. Allergy, immunodeficiency and epilepsy. Lancet 1975;11:975 [letter].

29. Egger J, Carter CM, Soothill JF, Wilson J. Oligoantigenic diet treatment of children with epilepsy and migraine. J Pediatr 1989;114:51-8.

30. Van Someren V, Robinson RO, McArdle B, Sturgeon N. Restricted diets for treatment of migraine. J Pediatr 1990;117:509-10 [letter].

31. Wilder RM. The effects of ketonemia on the course of epilepsy. Mayo Clinic Proc 1921;2:307-8.

32. Prasad AN, Stafstrom CF, Holmes GL. Alternative epilepsy therapies: the ketogenic diet, immunoglobulins, and steroids. Epilepsia 1996;37:S81-S95 [review].

33. Vining EP, Freemen JM, Ballaban-Gil K, et al. A multicenter study of the efficacy of the ketogenic diet. Arch Neurol 1998;55:1433-7.

34. Freeman JM, Vining EP, Pillas DJ, et al. The efficacy of the ketogenic diet-1998: a prospective evaluation of intervention in 150 children. Pediatrics 1998;102:1358-63.

35. Neelam GK, Koehler AN, McGhee B, et al. The ketogenic diet in refractory epilepsy: the experience of Children's Hospital of Pittsburgh. Clinical Pediatrics 2000;39:153-9.

36. Barborka CJ. Results of treatment by ketogenic diet in one hundred cases of epilepsy in adults. Assoc Res Nerv Ment Dis 1929;7:638-58.

37. Ballaban-Gil K, Callahan CM, O'Dell C, et al. The ketogenic diet in the treatment of intractable epilepsy in adults. Epilepsy 1996;37:92 [abstract].

38. Ballaban-Gil K, Callahan CM, O'Dell C, et al. Complications of the ketogenic diet. Epilepsia 1998;39:744-8.

39. Barron TF, Hunt SL. A review of the newer antiepileptic drugs and the ketogenic diet. Clin Pediatr (Phila) 1997;36:513-21.

40. Freeman JM, Kelly MT, Freeman JB. The epilepsy diet treatment. New York, NY: Demos, 1994.

41. Carroll J, Koenigsberger D. The ketogenic diet: a practical guide for caregivers. J Am Diet Assoc 1998;98:316-21.

42. http://www-leland.stanford.edu/group/ketodiet

Copyright © 2024 TraceGains, Inc. All rights reserved.

Learn more about TraceGains, the company.

The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.

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