Allergies And Sensitivities

Health Condition

Allergies and Sensitivities

  • Thymus Extracts

    Thymomodulin, a special preparation of the thymus gland of calves, has been shown to prevent allergic reactions to food in a double-blind study of allergic children.

    Dose:

    120 mg per day of thymomodulin
    Thymus Extracts
    ×
    Thymomodulin is a special preparation of the thymus gland of calves. In a double-blind study of allergic children who had successfully completed an elimination diet, 120 mg per day of thymomodulin prevented allergic skin reactions to food and lowered blood levels of antibodies associated with those foods.2 These results confirmed similar findings in an earlier, controlled trial.3
  • Flavonoids

    Test tube and animal studies have found some effects from natural antihistamines such as flavonoids, though no clinical research has shown whether these substances can specifically reduce allergic reactions.

    Dose:

    Refer to label instructions
    Flavonoids
    ×
     

    Many of the effects of allergic reactions are caused by the release of histamine, which is the reason antihistamine medication is often used by allergy sufferers. Some natural substances, such as vitamin C4,5 and flavonoids,6 including quercetin,7,8 have demonstrated antihistamine effects in test tube, animal, and other preliminary studies. However, no research has investigated whether these substances can specifically reduce allergic reactions in humans.

  • Quercetin

    Test tube and animal studies have found some effects from natural antihistamines such as the flavonoid quercetin, though no clinical research has shown whether these substances can specifically reduce allergic reactions.

    Dose:

    Refer to label instructions
    Quercetin
    ×
     

    Many of the effects of allergic reactions are caused by the release of histamine, which is the reason antihistamine medication is often used by allergy sufferers. Some natural substances, such as vitamin C9,10 and flavonoids,11 including quercetin,12,13 have demonstrated antihistamine effects in test tube, animal, and other preliminary studies. However, no research has investigated whether these substances can specifically reduce allergic reactions in humans.

What Are Star Ratings
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Reliable and relatively consistent scientific data showing a substantial health benefit.
Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Holistic Options

Acupuncture may be helpful in the treatment of some types of allergy. Studies of mice treated with acupuncture provide evidence of an anti-allergic effect with results similar to treatment with corticosteroids (cortisone-like drugs).14,15,16 A preliminary trial found a significant decrease in allergy symptoms following acupuncture treatment. It was found that the decline in symptoms coincided with a decline in laboratory measures of allergy. Relief persisted for two months following the treatment.17 Other preliminary trials have also demonstrated positive results.18 One controlled trial reported a reduction in allergic complaints following acupuncture treatment, but the results were not statistically significant.19 In the future, controlled trials with larger numbers of subjects may help to determine conclusively whether allergies can be successfully treated with acupuncture therapy.

Provocation-neutralization is a controversial method of both allergy testing and treatment. Treatment consists of injecting minute dilutions of foods, inhalants, or (in some cases) chemicals into the lower layers of the skin. This approach is not the same as traditional desensitization injections given by medical allergy specialists. Preliminary20,21 and double-blind22,23 research suggests treatment of allergies by provocation-neutralization may be effective, though negative double-blind research also exists.24

Allergy treatment using extracts of allergens taken orally is another controversial method advocated by some alternative healthcare practitioners.25 Most26,27,28,29 but not all double-blind trials30,31 have found this approach effective for house dust allergy. Preliminary32 and double-blind33,34,35 trials have reported success using this method for other allergies as well.

Treatment of food allergy using very small but increasing daily doses of actual foods has been reported,36 and in one controlled trial37 12 of 14 patients successfully completed the program and could tolerate previously allergenic foods.

All desensitization programs require the guidance of a healthcare professional. While none of these approaches has been unequivocally proven, several show promise that people with allergies may be treatable by means other than simple avoidance of the offending food or inhalant substance.

What tests can detect allergies? Several tests or procedures are used by physicians to detect allergies. Most of these tests remain controversial.38 Some clinicians (cited below), however, believe some of these tests can be effective.

Scratch testing

This form of testing is one of the most widely used. A patient’s skin is scratched with a needle that contains a portion of the food, inhalant, or chemical that is being tested. After a period of time, the skin is examined for reactions. If there is a reaction, it is determined that an allergy exists. Although this test is accepted by most allergists, scratch testing is subject to a relatively high incidence of inaccurate results, some tests showing positive when the person is not truly allergic to the substance (false positive) and some tests showing negative when an allergy really exists (false negative).

RAST/MAST/PRIST/ELISA (and other tests that measure immunoglobulins)

The radioallergosorbent test (RAST) indirectly measures antibodies in the blood that react to specific foods. It is used by many physicians and has been shown to be a somewhat reliable indicator of allergies.39,40 It does not, however, help diagnose non-allergic food sensitivities and is therefore associated with a high risk of false negative readings. In an attempt to avoid this problem, a variety of modifications have been made to tests related to RAST (such as MAST, PRIST, and ELISA). Some of these changes may have reduced the risk of false negative readings somewhat but are likely to have increased the risk of false positive readings. A number of conditions associated with food sensitivities, such as migraine headaches and irritable bowel syndrome, have shown remarkably poor correlation between RAST results and the actual sensitivities of patients.

Cytotoxic testing

The cytotoxic test views a patient’s serum under a microscope to see whether it is reacting to certain substances. The test is subject to numerous errors and is not generally considered to be reliable.41

Clinical ecology (provocation-neutralization; end-point titration)

This branch of medicine is considered very controversial. Testing is done using intra-dermal (under the skin) injections of minute dilutions of foods, inhalants or (in some cases) chemicals. Based on reactions, additional dilutions are used. This test not only determines whether an allergy exists but also operates on the theory that one dilution can trigger a reaction while another can neutralize a reaction. Preliminary research suggests this approach may have beneficial effects,20,21 A similar method uses these dilutions under the tongue to test for allergies.25 Double-blind research has not found this method effective. 45

Elimination and reintroduction

The most reliable way to determine a food allergy is to have the patient eliminate a suspected food from the diet for a period of time and then reintroduce it later. Once a food is eliminated, the symptoms it may be causing either improve or resolve, typically after several days to three weeks. The body then becomes more sensitive to the food, so when the food is reintroduced, the symptom is more likely to recur. This tool shows with a high degree of certainty which foods are problem foods. The testing requires a great deal of patience and, as with all other forms of allergy testing, is best undertaken with the help of a physician who can monitor the diet.46 Reintroduction of an allergenic food has been reported to lead occasionally to dangerous reactions in some people with certain conditions, particularly asthma—another reason this approach should not be attempted without supervision.

Other tests

Bioelectric tests are controversial procedures that attempt to measure changes in electrical activity at acupuncture points when a potential allergen is brought into proximity. A preliminary study reported that the EAV (Electroacupuncture According to Voll) device, also called the Vega test, identified the same allergens as RAST testing in 70.5 percent of tests.47 Another preliminary study found the Vega test identified the same neutralization doses as clinical ecology testing (see above) in 66% of tests.48 More research is needed to better evaluate these testing techniques.

References

1. David TJ. Adverse reactions and intolerance to foods. Br Med Bull 2000;56:34-50 [review].

2. Cavagni G, Piscopo E, Rigoli E, et al. Food allergy in children: an attempt to improve the effects of the elimination diet with an immunomodulating agent (thymomodulin). A double-blind clinical trial. Immunopharmacol Immunotoxicol 1989;11:131-42.

3. Genova R, Guerra A. Thymomodulin in management of food allergy in children. Int J Tissue React 1986;8:239-42.

4. Johnston CS, Retrum KR, Srilakshmi JC. Antihistamine effects and complications of supplemental vitamin C. J Am Diet Assoc 1992;92:988-9.

5. Johnston S, Martin LJ, Cai X. Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis. J Am Coll Nutr 1992;11:172-6.

6. Gabor M. Anti-inflammatory and anti-allergic properties of flavonoids. Prog Clin Biol Res 1986;213:471-80 [review].

7. Middleton E, Drzewieki G. Naturally occurring flavonoids and human basophil histamine release. Int Arch Allergy Appl Immunol 1985;77:155-7.

8. Amella M, Bronner C, Briancon F, et al. Inhibition of mast cell histamine release by flavonoids and bioflavonoids. Planta Medica 1985;51:16-20.

9. Johnston CS, Retrum KR, Srilakshmi JC. Antihistamine effects and complications of supplemental vitamin C. J Am Diet Assoc 1992;92:988-9.

10. Johnston S, Martin LJ, Cai X. Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis. J Am Coll Nutr 1992;11:172-6.

11. Gabor M. Anti-inflammatory and anti-allergic properties of flavonoids. Prog Clin Biol Res 1986;213:471-80 [review].

12. Middleton E, Drzewieki G. Naturally occurring flavonoids and human basophil histamine release. Int Arch Allergy Appl Immunol 1985;77:155-7.

13. Amella M, Bronner C, Briancon F, et al. Inhibition of mast cell histamine release by flavonoids and bioflavonoids. Planta Medica 1985;51:16-20.

14. Kasahara T, Amemiya M, Wu Y, Oguchi K. Involvement of central opioidergic and nonopioidergic neuroendocrine systems in the suppressive effect of acupuncture on delayed type hypersensitivity in mice. Int J Immunopharmacol 1993;15:501-8.

15. Kasahara T, Wu Y, Sakurai Y, Oguchi K. Suppressive effect of acupuncture on delayed type hypersensitivity to trinitrochlorobenzene and involvement of opiate receptors. Int J Immunopharmacol 1992;14:661-5.

16. Jian M. Influence of adrenergic antagonist and naloxone on the anti-allergic shock effect of electro-acupuncture in mice. Acupunct Electrother Res 1985;10:163-7.

17. Lau BH, Wong DS, Slater JM. Effect of acupuncture on allergic rhinitis: clinical and laboratory evaluations. Am J Chin Med 1975;3:263-70.

18. Lai X. Observation on the curative effect of acupuncture on type I allergic diseases. J Tradit Chin Med 1993;13:243-8.

19. Wolkenstein E, Horak F. [Protective effect of acupuncture on allergen provoked rhinitis]. Wien Med Wochenschr 1998;148:450-3 [in German].

20. Miller JB. A double-blind study of food extract injection therapy: a preliminary report. Ann Allerg 1977:185-91.

21. Hosen H. Provocative testing for food allergy diagnosis. J Asthma Res 1976:45-51.

22. Rea WJ, Podell RN, Williams ML, et al. Elimination of oral food challenge reaction by injection of food extracts. A double-blind evaluation. Arch Otolaryngol 1984;110:248-52.

23. King WP, Fadal RG, Ward WA, et al. Provocation-neutralization: a two-part study. Part II. Subcutaneous neutralization therapy: a multi-center study. Otolaryngol Head Neck Surg 1988;99:272-7.

24. Jewett DL, Fein G, Greenberg MH. A double-blind study of symptom provocation to determine food sensitivity. New Engl J Med 1990;323:429-33.

25. Morris DL. Use of sublingual antigen in diagnosis and treatment of food allergy. Ann Allergy 1969;27:289-94.

26. Scadding GK, Brostoff J. Low dose sublingual therapy in patients with allergic rhinitis due to house dust mite. Clin Allergy 1986;16:483-91.

27. Tari MG, Mancino M, Monti G. Efficacy of sublingual immunotherapy in patients with rhinitis and asthma due to house dust mite. A double-blind study. Allergol Immunopathol (Madr) 1990;18:277-84.

28. Bousquet J, Scheinmann P, Guinnepain MT, et al. Sublingual-swallow immunotherapy (SLIT) in patients with asthma due to house-dust mites: a double-blind, placebo-controlled study. Allergy 1999;54:249-60.

29. Mungan D, Misirligil Z, Gurbuz L. Comparison of the efficacy of subcutaneous and sublingual immunotherapy in mite-sensitive patients with rhinitis and asthma—a placebo controlled study. Ann Allergy Asthma Immunol 1999;82:485-90.

30. Urbanek R, Gehl R. Efficacy of oral hyposensitization treatment in house dust mite allergy. Monatsschr Kinderheilkd 1982;130:150-2 [in German].

31. Guez S, Vatrinet C, Fadel R, Andre C. House-dust-mite sublingual-swallow immunotherapy (SLIT) in perennial rhinitis: a double-blind, placebo-controlled study. Allergy 2000;55:369-75.

32. Mastrandrea F, Serio G, Minelli M, et al. Specific sublingual immunotherapy in atopic dermatitis. Results of a 6-year follow-up of 35 consecutive patients. Allergol Immunopathol (Madr) 2000;28:54-62.

33. Passalacqua G, Albano M, Riccio A, et al. Clinical and immunologic effects of a rush sublingual immunotherapy to Parietaria species: A double-blind, placebo-controlled trial. J Allergy Clin Immunol 1999;104:964-8.

34. Pradalier A, Basset D, Claudel A, et al. Sublingual-swallow immunotherapy (SLIT) with a standardized five-grass-pollen extract (drops and sublingual tablets) versus placebo in seasonal rhinitis. Allergy 1999;54:819-28.

35. Sabbah A. Specific immunotherapy using allergens apropos of specific immunotherapy by the sublingual route. Allerg Immunol (Paris) 1998;30:221-8 [review; in French].

36. Patriarca C, Romano A, Venuti A, et al. Oral specific hyposensitization in the management of patients allergic to food. Allergol Immunopathol (Madr) 1984;12:275-81.

37. Patriarca G, Schiavino D, Nucera E, et al. Food allergy in children: results of a standardized protocol for oral desensitization. Hepatogastroenterology 1998;45:52-8.

38. Am Academy of Allergy. Position statements: controversial techniques. J Allergy Clin Immunol 1981:333-8.

39. Gleich G, Yunginger J. The radioallergosorbent test: its present place and likely future in the practice of allergy. Adv Asthma Allergy 1975(Spring):1.

40. Wraith DG. Recognition of food-allergic patients and their allergens by the RAST technique and clinical investigation. Clin Allergy 1979:25-36.

41. Lieberman P, et al. Controlled study of the cytotoxic food test. JAMA 1975:728-30.

42. Lehman CW. A double-blind study of sublingual provocative food testing: a study of its efficacy. Ann Allergy 1980;45:144-9.

43. Mandell M. Dr. Mandell's 5-Day Allergy Relief System. New York: Pocket Books, 1979.

44. Tsuei JJ, Lehman CW, Lam FMK, et al. A food allergy study using the EAV acupuncture technique. Am J Acupuncture 1984;12:105-16.

45. Krop J, Swierczek J, Wood A. Comparison of ecological testing with the Vega test method in identifying sensitivities to chemicals, foods and inhalents. Am J Acupuncture 1985;13:253-9.

46. Bahna SL. Management of food allergies. Ann Allergy 1984;53:678-82 [review].

47. Crook WG. Detecting your hidden food allergies. Jackson, TN: Professional Books, 1988.

48. Mandell M. Dr. Mandell's 5-Day Allergy Relief System. New York: Pocket Books, 1979.

49. Sampson HA. Food allergy. Part 2: diagnosis and management. J Allergy Clin Immunol 1999;103:981-9 [review].

50. Klein GL. Controlling allergies by controlling environment. A big help for your patients. Postgrad Med 1992;91:215-8, 221-4 [review].

Copyright © 2024 TraceGains, Inc. All rights reserved.

Learn more about TraceGains, the company.

The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.

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