Abnormal Pap Smear

Health Condition

Abnormal Pap Smear

  • Folic Acid

    Large amounts of folic acid have been shown to improve the abnormal Pap smears of some women who are taking birth control pills.

    Dose:

    10 mg daily under medical supervision
    Folic Acid
    ×
     

    Large amounts of folic acid—10 mg per day—have been shown to improve the abnormal Pap smears of women who are taking birth control pills.1 Folic acid does not improve the Pap smears of women who are not taking oral contraceptives.2,3 High blood levels of folate (the food form of folic acid) have been linked to protection against the development of cervical dysplasia but these higher levels may only be a marker for eating more fruit and vegetables.4,5

  • Green Tea

    A preliminary study found that cervical dysplasia improved following treatment with epigallocatechin-3-gallate, a green tea flavonoid, for 8 to 12 weeks.

    Dose:

    Twice weekly, apply a cream with 15% polyphenols to the cervix and/or take a 200 mg EGCG supplement daily  
    Green Tea
    ×
     

    In a preliminary study, women with cervical dysplasia were randomly assigned to receive either 200 mg per day of EGCG—a green tea extract known as (-)-epigallocatechin-3-gallate—200 mg per day of poly E (another green tea extract), or no treatment (control group) for 8 to 12 weeks. More than 50% of the women receiving EGCG or poly E had an improvement in their Pap smear, compared with only 10% of the women in the control group.6

  • Echinacea, Goldenseal, Marshmallow, Myrrh, Usnea, and Yarrow Suppository

    Though not proven in clinical trials, these herbs are used for their antiviral actions and thought to stimulate tissue healing. Consult a healthcare professional.

    Dose:

    Refer to label instructions
    Echinacea, Goldenseal, Marshmallow, Myrrh, Usnea, and Yarrow Suppository
    ×
     

    Several other herbs have been used as part of an approach for women with mild cervical dysplasia, including myrrh, echinacea, usnea, goldenseal, marshmallow, and yarrow.7 These herbs are used for their antiviral actions as well as to stimulate tissue healing; they are generally administered in a suppository preparation. No clinical trials have proven their effectiveness in treating cervical dysplasia. A doctor should be consulted to discuss the use and availability of these herbs.

  • Selenium

    Low levels of selenium have been observed in women with cervical dysplasia.

    Dose:

    Refer to label instructions
    Selenium
    ×
     

    Low levels of selenium8 and low dietary intake of vitamin C9,10 have been observed in women with cervical dysplasia.

  • Vitamin A

    Women who don’t get enough vitamin A have an increased risk of cervical dysplasia, though there is little research on using vitamin A as a treatment.

    Dose:

    Refer to label instructions
    Vitamin A
    ×

    Women with a low intake of vitamin A have an increased risk of cervical dysplasia.11 However, there is little research on the use of vitamin A as a treatment for cervical dysplasia.

     
  • Vitamin E

    Women with cervical dysplasia may have lower blood levels of vitamin E compared with healthy women.

    Dose:

    Refer to label instructions
    Vitamin E
    ×
     

    Women with cervical dysplasia may have lower blood levels of beta-carotene and vitamin E12,13 compared to healthy women.

What Are Star Ratings
×
Reliable and relatively consistent scientific data showing a substantial health benefit.
Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

References

1. Butterworth CE Jr, Hatch KD, Gore H, et al. Improvement in cervical dysplasia associated with folic acid therapy in users of oral contraceptives. Am J Clin Nutr 1982;35:73-82.

2. Zarcone R, Bellini P, Carfora E, et al. Folic acid and cervix dysplasia. Minerva Ginecol 1996;48:397-400.

3. Butterworth CE, Hatch KD, Soong S-J, et al. Oral folic acid supplementation for cervical dysplasia: A clinical intervention trial. Am J Obstet Gynecol 1992;166:803-9.

4. Butterworth CE Jr, Hatch KD, Macaluso M, et al. Folate deficiency and cervical dysplasia. JAMA 1992;267:528-33.

5. Piyathilake CJ, Macaluso M, Brill I, et al. Lower red blood cell folate enhances the HPV-16-associated risk of cervical intraepithelial neoplasia. Nutrition 2007;23:203-10.

6. Ahn WS, Yoo J, Huh SW, et al. Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions. Eur J Cancer Prev 2003;12:383-90.

7. Hudson T. Women's Encyclopedia of Natural Medicine. Lincolnwood, IL: Keats, 1999, 54.

8. Dawson EB, Nosovitch JT, Hannigan EV. Serum vitamin and selenium changes in cervical dysplasia. Fed Proc 1984;43:612.

9. Wassertheil-Smoller S, Romney SL, Wylie-Rosett J, et al. Dietary vitamin C and uterine cervical dysplasia. Am J Epidemiol 1981;114:714-24.

10. Ho GY, Palan PR, Basu J, et al. Viral characteristics of human papillomavirus infection and antioxidant levels as risk factors for cervical dysplasia. Int J Cancer 1998;78:594-9.

11. Romney SL, Palan PR, Duttagupta C, et al. Retinoids and the prevention of cervical dysplasias. Am J Obstet Gynecol 1981;141:890-4.

12. Palan PR, Mikhail MS, Basu J, Romney SL. Plasma levels of antioxidant beta-carotene and alpha-tocopherol in uterine cervix dysplasias and cancer. Nutr Cancer l991;15:13-20.

13. Ho GY, Palan PR, Basu J, et al. Viral characteristics of human papillomavirus infection and antioxidant levels as risk factors for cervical dysplasia. Int J Cancer 1998;78:594-9.

14. Kwasniewska A, Charzewska J, Tukendorf A, Semczuk M. Dietary factors in women with dysplasia colli uteri associated with human papillomavirus infection. Nutr Cancer 1998;30:39-45.

15. Romney SL, Palan PR, Basu J, Mikhail M. Nutrient antioxidants in the pathogenesis and prevention of cervical dysplasias and cancer. J Cell Biochem Suppl 1995;23:96-103 [review].

16. Ziegler RG, Jones CJ, Brinton LA, et al. Diet and the risk of in situ cervical cancer among white women in the United States. Cancer Causes Control 1991;2:17-29.

17. Kantesky PA, Gammon MD, Mandelblatt J, et al. Dietary intake and blood levels of lycopene: association with cervical dysplasia among non-Hispanic, black women. Nutr Cancer 1998;31:31-40.

18. VanEenwyk J, Davis FG, Bowen PE. Dietary and serum carotenoids and cervical intraepithelial neoplasia. Int J Cancer 1991;48:34-8.

19. de Vet HC, Sturmans F. Risk factors for cervical dysplasia: implications for prevention. Public Health 1994;108:241-9.

20. Becker TM, Wheeler CM, McGough NS, et al. Cigarette smoking and other risk factors for cervical dysplasia in southwestern Hispanic and non-Hispanic white women. Cancer Epidemiol Biomarkers Prev 1994;3:113-9.

21. Kanetsky PA, Gammon MD, Mandelblatt J, et al. Cigarette smoking and cervical dysplasia among non-Hispanic black women. Cancer Detect Prev 1998;22:109-19.

22. Daly SF, Doyle M, English J, et al. Can the number of cigarettes smoked predict high-grade cervical intraepithelial neoplasia among women with mildly abnormal cervical smears? Am J Obstet Gynecol 1998;179:399-402.

23. Cerqueira EM, Santoro CL, Donozo NF, et al. Genetic damage in exfoliated cells of the uterine cervix. Association and interaction between cigarette smoking and progression to malignant transformation? Acta Cytol 1998;42:639-49.

24. Brinton LA. Epidemiology of cervical cancer—overview. In Munoz N, Bosch FX, Shah KV, Meheus A, eds. The epidemiology of cervical cancer and human papillomavirus. Lyon, France: IARC, 1992, 3-23.

25. Parazzini F, Negri E, La Vecchia C, Fedele L. Barrier methods of contraception and the risk of cervical neoplasia. Contraception 1989;40:519-30.

26. Coker AL, Hulka BS, McCann MF, Walton LA. Barrier methods of contraception and cervical intraepithelial neoplasia. Contraception 1992;45:1-10.

27. Becker TM, Wheeler CM, McGough NS, et al. Contraceptive and reproductive risks for cervical dysplasia in southwestern Hispanic and non-Hispanic white women. Int J Epidemiol 1994;23:913-22.

Copyright © 2024 TraceGains, Inc. All rights reserved.

Learn more about TraceGains, the company.

The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.

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