Lesinurad is used with another medication (such as allopurinol, febuxostat) to lower uric acid levels in people with gout. It works by helping the kidneys get rid of uric acid from the body. Increased uric acid levels can cause gout.
Lesinurad has caused very serious kidney problems, especially when it is used alone to lower uric acid levels. It should always be used in combination with another medication. If you need to stop your other uric acid medication, then you should also stop this medication. Consult your doctor for more details.
How to Use This Medication
See also Warning section.
Read the Medication Guide provided by your pharmacist before you start taking lesinurad and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth with food as directed by your doctor, usually once daily in the morning with your other uric acid medication. Drink a full glass of water with each dose and at least another 8 glasses (8 ounces each) a day while taking this drug. If you are on restricted fluid intake, consult your doctor for further instructions.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.
You may have more gout attacks after starting this medicine while your body removes extra uric acid. Lesinurad is not a pain reliever. Your doctor may prescribe medication (including colchicine, NSAIDs such as ibuprofen, naproxen, or indomethacin) to prevent/treat a gout attack while you are taking lesinurad. Continue to take lesinurad and your prescribed medicines for gout attacks as directed by your doctor. Tell your doctor if your condition lasts or gets worse.