Colchicine-Probenecid Explained

Colchicine-Probenecid

Pronounced

"COAL-cheh-seen/pro-BEN-uh-sid"

Drug Interactions

See also How to Use and Precautions sections.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: drugs that can increase uric acid in the blood (such as pyrazinamide).

This medication can slow down the removal of other medications from your body, which may affect how they work or increase the risk of serious side effects. Examples include baricitinib, ceftazidime/avibactam, fosfomycin, ketoprofen, ketorolac, methotrexate, pralatrexate, among others.

Other medications can affect the removal of this medication from your body, which may affect how this drug works or increase the risk of serious side effects. Examples include atazanavir, certain azole antifungals (such as itraconazole, ketoconazole), diltiazem, macrolide antibiotics (such as clarithromycin, erythromycin), ritonavir, telithromycin, verapamil, among others.

This medication may rarely cause a certain serious (even fatal) muscle damage (rhabdomyolysis). This muscle damage releases substances that can lead to serious kidney problems. The risk may be increased if other drugs that may also cause rhabdomyolysis are taken along with this drug. Some affected drugs include: digoxin, gemfibrozil, pravastatin, simvastatin, among others.

This medication may interfere with certain lab tests (such as urine glucose tests), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Negative Interactions
1
- Colchicine
  Teas and Herbs with Tannin
  Reduces Effectiveness
  Tannins are a group of unrelated chemicals that give plants an astringent taste. Herbs with large amounts of tannins may interfere with the absorption of codeine and should not be taken together with codeine or codeine-containing products. Herbs containing high levels of tannins include green tea (Camellia sinensis), black tea, uva ursi (Arctostaphylos uva-ursi), black walnut (Juglans nigra),red raspberry (Rubus idaeus),oak (Quercus spp.), and witch hazel (Hamamelis virginiana).
  Teas and Herbs with Tannin
  Colchicine
  ×
  1. Brinker F. Interactions of pharmaceutical and botanical medicines. J Naturopathic Med 1997;7(2):14-20.
Supportive Interactions
4
- Colchicine
  Beta-Carotene
  Replenish Depleted Nutrients
  Colchicine has been associated with impaired absorption of beta-carotene, fat, lactose (milk sugar), potassium, and sodium.
  Beta-Carotene
  Colchicine
  ×
  1. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 223-4 [review].
- Colchicine
  Potassium
  Replenish Depleted Nutrients
  Colchicine has been associated with impaired absorption of beta-carotene, fat, lactose (milk sugar), potassium, and sodium.
  Potassium
  Colchicine
  ×
  1. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 223-4 [review].
- Colchicine
  Sodium
  Replenish Depleted Nutrients
  Colchicine has been associated with impaired absorption of beta-carotene, fat, lactose (milk sugar), potassium, and sodium.
  Sodium
  Colchicine
  ×
  1. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 223-4 [review].
- Colchicine
  Vitamin B12
  Replenish Depleted Nutrients
  Colchicine may interfere with vitamin B12 in the body. Research is inconsistent. Both colchicine and vitamin B12 deficiency are reported to cause neuropathies (disorders of the nervous system), but it remains unclear whether neuropathies caused by colchicine could be due to vitamin B12 depletion.
  Vitamin B12
  Colchicine
  ×
  1. Palopoli JJ, Waxman J. Colchicine neuropathy or vitamin B12 deficiency neuropathy? N Engl J Med 1987;317:1290 [letter].
  2. Kuncl RW et al. Colchicine neuropathy or vitamin B12 deficiency neuropathy? N Engl J Med 1987;317:1290-1 [letter].

Colchicine Probenecid

Drug