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ESTRADIOL (es tra DYE ole) relieves the symptoms of menopause, such as hot flashes or vaginal dryness. It may also be used to treat low estrogen levels. It is also used to reduce the symptoms of prostate cancer. It works by increasing levels of the hormone estrogen in the body. This medication is an estrogen hormone.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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This medication is for injection into a muscle. It is usually given in a hospital or clinic.
A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.
Talk to your care team about the use of this medication in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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Do not take this medication with any of the following:
-Aromatase inhibitors, such as aminoglutethimide, anastrozole, exemestane, letrozole, testolactone
This medication may also interact with the following:
-Carbamazepine
-Certain antibiotics used to treat infections
-Certain barbiturates or benzodiazepines used for inducing sleep or treating seizures
-Grapefruit juice
-Medications for fungus infections, such as itraconazole and ketoconazole
-Raloxifene or tamoxifen
-Rifabutin, rifampin, or rifapentine
-Ritonavir
-St. John's Wort
-Warfarin
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Visit your care team for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medication. You should also discuss the need for regular mammograms with your care team, and follow their guidelines for these tests.
This medication can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your care team if you feel you are retaining fluid.
Talk to your care team if you wish to become pregnant or think you might be pregnant. This medication can cause serious birth defects.
Smoking tobacco increases the risk of getting a blood clot or having a stroke while you are taking this medication, especially if you are older than 35 years.
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your care team.
This medication can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone medication, with this medication lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your care team may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your care team to determine the benefits and risks for you.
If you are going to have surgery, let your care team know you are receiving estrogen. Consult your care team for advice before you schedule the surgery.
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It is important not to miss your dose. Call your care team if you are unable to keep an appointment.
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Side effects that you should report to your care team as soon as possible:
-Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
-Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain
-Breast tissue changes, new lumps, redness, pain, or discharge from the nipple
-Gallbladder problems—severe stomach pain, nausea, vomiting, fever
-Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
-Heavy vaginal bleeding
-Increase in blood pressure
-Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
-Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
-Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
-Unusual vaginal discharge, itching, or odor
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
-Bloating
-Breast pain or tenderness
-Dark patches of skin on the face or other sun-exposed areas
-Hair loss
-Irregular menstrual cycles or spotting
-Nausea
-Stomach pain
-Swelling of the ankles, hands, or feet
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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This medication is given in a hospital or clinic and will not be stored at home.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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