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COTELLIC
- QTY 63
- 20 MG
- Tablet
- Near 77381
COBIMETINIB (KOE bi ME ti nib) treats skin cancer. It may also be used to treat blood and bone marrow cancers. It works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.
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COTELLIC
- QTY 63
- 20 MG
- Tablet
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COTELLIC
- QTY 63
- 20 MG
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COTELLIC Lifestyle Interactions
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Cobimetinib 20mg, Oral tablet
• Interaction: Grapefruit juice• Severity: Major• Notes for Consumers: Do not take Cobimetinib with Grapefruit Juice. Side effects from Cobimetinib may get worse if you take Grapefruit Juice.• Notes for Professionals: Avoid the concurrent use of cobimetinib with grapefruit juice due to the risk of cobimetinib toxicity. Cobimetinib is a CYP3A substrate in vitro, and grapefruit juice is a strong inhibitor of CYP3A. In healthy subjects (n = 15), coadministration of a single 10 mg dose of cobimetinib with itraconazole (200 mg once daily for 14 days), another strong CYP3A4 inhibitor, increased the mean cobimetinib AUC by 6.7-fold (90% CI, 5.6 to 8) and the mean Cmax by 3.2-fold (90% CI, 2.7 to 3.7).
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
