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    • COLD RELIEF PLUS (Generic for ALKA-SELTZER PLUS COLD)

COLD RELIEF PLUS (Generic for ALKA-SELTZER PLUS COLD) Lifestyle Interactions

  • Aspirin 325mg, Chlorpheniramine Maleate 2mg, Phenylephrine Bitartrate 7.8mg, Effervescent tablet

    • Interaction: Alcohol
    • Severity: Major
    • Notes for Consumers: Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication increases the risk of stomach bleeding. Contact your care team right away if you experience bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds.
    • Notes for Professionals: Concomitant ingestion of alcohol with salicylates, especially aspirin, ASA, increases the risk of developing gastric irritation and GI mucosal bleeding. Alcohol and salicylates are mucosal irritants and aspirin decreases platelet aggregation. Routine ingestion of alcohol and aspirin can cause significant GI bleeding, which may or may not be overt. Even occasional concomitant use of salicylates and alcohol should be avoided. Chronic ingestion of alcohol is often associated with hypoprothrombinemia and this condition increases the risk of salicylate-induced bleeding. Patients should be warned regarding the potential for increased risk of GI bleeding if alcohol-containing beverages are taken concurrently with salicylates.

  • Aspirin 325mg, Chlorpheniramine Maleate 2mg, Phenylephrine Bitartrate 7.8mg, Effervescent tablet

    • Interaction: Cannabis
    • Severity: Major
    • Notes for Consumers: Discuss cannabis use with your care team. The effects of your medication may be altered if used with cannabis. Call emergency services right away if you experience slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, or trouble staying awake.
    • Notes for Professionals: Advise patients to avoid cannabis use while taking CNS depressants due to the risk for additive CNS depression and potential for other cognitive adverse reactions.

  • Aspirin 325mg, Chlorpheniramine Maleate 2mg, Phenylephrine Bitartrate 7.8mg, Effervescent tablet

    • Interaction: Caffeine-containing Foods/Beverages
    • Severity: Moderate
    • Notes for Consumers: Limit caffeine intake (examples: coffee, teas, colas, chocolate and some herbal supplements) while taking Phenylephrine. Also avoid medicines containing additional Caffeine whenever possible. Side effects from Phenylephrine may get worse if you take excessive Caffeine. Taking a high amount of Caffeine can increase the risk of nausea, nervousness, palpitations, problems with sleep, rapid heartbeat, tremor, or other side effects.
    • Notes for Professionals: Caffeine is a CNS-stimulant and such actions are expected to be additive when coadministered with other CNS stimulants or psychostimulants.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.