• Image of Cafergot medication Image of Cafergot medication

    • ERGOTAMINE-CAFFEINE (Generic for CAFERGOT)

ERGOTAMINE; CAFFEINE (er GOT a meen; KAF een) treats migraines. It works by blocking pain signals and narrowing blood vessels in the brain. It is a combination of an ergot alkaloid and caffeine. It is not used to prevent migraines.

ERGOTAMINE-CAFFEINE (Generic for CAFERGOT) Lifestyle Interactions

  • Ergotamine Tartrate 1mg, Caffeine 100mg, Caffeine, Anhydrous 100mg, Oral tablet

    • Interaction: Tobacco
    • Severity: Major
    • Notes for Consumers: Do not smoke or use tobacco products while taking this medication. Smoking while taking this medication increases the risk for serious side effects. Contact your care team if you experience new or worsening side effects.
    • Notes for Professionals: Advise patients to avoid smoking tobacco while taking ergot alkaloids. Concurrent use of vasoconstrictors, such as nicotine, with ergot alkaloids may result in enhanced vasoconstriction. Nicotine acts indirectly as a sympathomimetic agent by releasing catecholamines, potentially resulting in effects such as hypertension, coronary spasm, coronary ischemia, or cardiac arrhythmias, which may be additive with ergot alkaloids.

  • Ergotamine Tartrate 1mg, Caffeine 100mg, Caffeine, Anhydrous 100mg, Oral tablet

    • Interaction: Grapefruit juice
    • Severity: Mild
    • Notes for Consumers: Do not significantly alter your grapefruit juice intake while taking medicines containing caffeine. Some reports suggest that intake of grapefruit juice can increase side effects from caffeine. Too much Caffeine can cause effects like nausea, tremor, nervousness, or sleeplessness. If these occur, consider ingesting less caffeine daily.
    • Notes for Professionals: Data are limited and conflicting as to whether grapefruit juice significantly alters the serum concentrations and/or AUC of caffeine. Caffeine is primarily a CYP1A2 substrate, and grapefruit juice appears to have but a small effect on this enzyme in vivo. One report suggests that grapefruit juice decreases caffeine elimination by inhibition of flavin-containing monooxygenase, a P450 independent system. This interaction might increase caffeine levels and mildly potentiate the clinical effects and common side effects of caffeine. If side effects appear, patients may need to limit either caffeine or grapefruit juice intake.

  • Ergotamine Tartrate 1mg, Caffeine 100mg, Caffeine, Anhydrous 100mg, Oral tablet

    • Interaction: Caffeine-containing Foods/Beverages
    • Severity: Moderate
    • Notes for Consumers: While taking Caffeine-containing medicines, limit the use of foods, beverages (examples: coffee, tea, colas), herbs (examples: guarana, green tea) and other products that contain additional caffeine, such as chocolate and some non-prescription medications or dietary supplements for headache, insomnia, or weight loss. Too much Caffeine can cause effects like nausea, nervousness, or sleeplessness. Some drug products for adults that contain caffeine have about as much caffeine as a cup of coffee.
    • Notes for Professionals: Certain foods that contain high amounts of caffeine or theobromine should be limited during the therapeutic use of caffeine in order to limit additive methylxanthine effects. While taking Caffeine-containing medicines, limit the use of foods, beverages (examples: coffee, tea, colas), herbs (examples: guarana, green tea) and other products that contain additional caffeine, such as chocolate and some non-prescription medications or dietary supplements for headache, insomnia, or weight loss. Too much Caffeine can cause effects like nausea, nervousness, or sleeplessness. Some drug products for adults that contain caffeine have about as much caffeine as a cup of coffee.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.