ZONTIVITY

Vorapaxar 2.08mg, Oral tablet

Grapefruit juice

· Severity: Moderate

· Notes for Consumers: These drugs may be taken together only under close supervision from your prescriber. Taking these drugs together may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding. Signs of bleeding may include bloody or black, tarry stools; red or dark-brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eye, gums, or nose.

· Notes for Professionals: Use caution during concurrent use of vorapaxar and grapefruit juice. Increased serum concentrations of vorapaxar are possible when vorapaxar, a CYP3A4 substrate, is coadministered with grapefruit juice, a CYP3A inhibitor. Increased exposure to vorapaxar may increase the risk of bleeding complications.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>