NUEDEXTA
  • NUEDEXTA

  • QTY 60 • 20 MG-10MG • Capsule • Near 77381

DEXTROMETHORPHAN; QUINIDINE (dex troe meth OR fan; KWIN i deen) is a combination of two medicines used to treat pseudobulbar affect (PBA), a condition that causes uncontrollable, sudden, and frequent episodes of laughing and/or crying.

NUEDEXTA Lifestyle Interactions

Dextromethorphan Hydrobromide 20mg, Quinidine Sulfate 10mg, Oral capsule

Grapefruit juice

· Severity: Major

· Notes for Consumers: Side effects from Quinidine may get worse if you take Grapefruit juice. Do not take Quinidine and Grapefruit juice together. Grapefruit juice can raise the level of Quinidine in the blood, which could increase the chance of side effects from Quinidine such as nausea/vomiting, a slow heart rate, or dizziness. Contact your prescriber immediately if you experience fainting or falling spells, palpitations, shortness of breath, or a change in your usual heart beat (fast, slow, or irregular heart beat) while taking Quinidine. Discuss with your health care provider why you should avoid grapefruit juice intake when taking Quinidine.

· Notes for Professionals: Grapefruit juice contains an unknown compound that inhibits cytochrome P-450 3A4 isozymes in the gut wall. Coadministration of quinidine with grapefruit juice to healthy volunteers delayed quinidine absorption and inhibited the conversion of quinidine to the major metabolite. Although the clinical significance of the interaction is unknown, concomitant administration with grapefruit juice should be avoided.

Dextromethorphan Hydrobromide 20mg, Quinidine Sulfate 10mg, Oral capsule

Grapefruit juice

· Severity: Mild

· Notes for Consumers: Grapefruit juice may increase the actions of Dextromethorphan, which may make some people feel drowsiness or other side effects (dizziness, nervousness or restlessness, nausea, vomiting, stomach upset) of Dextromethorphan that do not usually occur with prescribed or nonprescription product doses. It may be best to limit intake of grapefruit juice while you are taking Dextromethorphan-containing products.

· Notes for Professionals: Intake of grapefruit juice or seville orange juice increased dextromethorphan bioavailability in one study. Patients with increased concentrations of dextromethorphan may experience drowsiness or serotonergic side effects (dizziness, nervousness or restlessness, nausea, vomiting, stomach upset) not usually noted with prescribed or nonprescription product doses. Grapefruit juice and seville orange juice contain compounds that can inhibit P-glycoprotein in the intestinal wall, and dextromethorphan absorption may be affected by P-glycoprotein activity. Dextromethorphan is largely metabolized by CYP2D6, so this particular interaction with grapefruit juice may be more relevant in patients who are poor CYP2D6 metabolizers.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>

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