HYDROCODONE-ACETAMINOPHEN
  • HYDROCODONE-ACETAMINOPHEN

  • (Generic for NORCO)
  • QTY 12 • 5 MG-325MG • Tablet • Near 77381

ACETAMINOPHEN; HYDROCODONE (a set a MEE noe fen; hye droe KOE done) is a pain reliever. It is used to treat moderate to severe pain.

HYDROCODONE-ACETAMINOPHEN Lifestyle Interactions

Hydrocodone Bitartrate 5mg, Acetaminophen 325mg, Oral tablet

Alcohol

· Severity: Major

· Notes for Consumers: Patients who drink more than 3 alcohol-containing drinks a day and take Acetaminophen are at increased risk of developing liver side effects. Limit alcohol intake while taking Acetaminophen. Avoid alcohol-containing drinks if you are taking Acetaminophen on a regular basis.

· Notes for Professionals: The risk of developing hepatotoxicity from acetaminophen appears to be increased in patients who regularly consume alcohol. Patients who drink more than 3 alcohol-containing drinks a day and take acetaminophen are at increased risk of developing hepatotoxicity. Acute or chronic alcohol use increases acetaminophen-induced hepatotoxicity by inducing cytochrome P450 CYP 2E1 leading to increased formation of the hepatotoxic metabolite of acetaminophen. Also, chronic alcohol use can deplete liver glutathione stores. Administration of acetaminophen should be limited or avoided altogether in patients with alcoholism or patients who consume alcohol regularly.

Hydrocodone Bitartrate 5mg, Acetaminophen 325mg, Oral tablet

Grapefruit juice

· Severity: Moderate

· Notes for Consumers: It is recommended that you limit and do not significantly alter your intake of grapefruit or grapefruit juice while taking hydrocodone. Side effects from hydrocodone may get worse if you increase your intake of grapefruit juice. Talk to your doctor first. Contact your doctor right away if you have symptoms of hydrocodone side effects such as slurred speech, confusion, weakness, or trouble breathing. Do not drive or operate machinery until you know how hydrocodone affects you.

· Notes for Professionals: Patients should not significantly alter their intake of grapefruit or grapefruit juice during therapy with hydrocodone. Grapefruit juice, a CYP3A4 inhibitor, may increase plasma concentrations of hydrocodone, a CYP3A4 substrate. This may increase or prolong hydrocodone-related toxicities including respiratory depression. Advise patients accordingly; patient monitoring and dosage adjustments may be necessary if grapefruit is consumed regularly.

Hydrocodone Bitartrate 5mg, Acetaminophen 325mg, Oral tablet

Alcohol

· Severity: Major

· Notes for Consumers: Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication increases the risk of an opioid overdose. Symptoms of an overdose may include slow or shallow breathing, difficulty staying awake, or the inability to respond or wake up. Call emergency services right away if you experience these symptoms. Talk to your care team about naloxone, a medication for the emergency treatment of opioid overdose.

· Notes for Professionals: Advise patients to avoid alcohol consumption while taking opioids. Alcohol consumption may result in additive CNS depression and may increase the risk for opioid overdose. Alcohol may also increase opioid drug exposure and the risk for fatal overdose by disrupting extended- or delayed-release opioid formulations. Consider the patient's use of alcohol when prescribing opioid medications. If the patient is unlikely to be compliant with avoiding alcohol, consider prescribing naloxone especially if additional risk factors for opioid overdose are present.

Hydrocodone Bitartrate 5mg, Acetaminophen 325mg, Oral tablet

Tobacco

· Severity: Moderate

· Notes for Consumers: If you are a tobacco smoker, use of Acetaminophen can increase the risk of liver side effects. Immediately tell your doctor if you get severe abdominal pain, nausea, vomiting, or yellowing of the skin. Do not exceed 4 g acetaminophen/day in adults. Tell your doctor if Acetaminophen does not help your headache or other pain. Tobacco smoke may reduce the effectiveness of Acetaminophen.

· Notes for Professionals: Tobacco smoking induces the cytochrome P450 isoenzyme CYP1A2 and may potentially increase the risk for acetaminophen-induced hepatotoxicity during overdose via enhanced generation of acetaminophen's hepatotoxic metabolite, NAPQI. In one study, current tobacco smoking was found to be very frequent in patients admitted with acetaminophen poisoning. Tobacco smoking appears to be an independent risk factor of severe hepatotoxicity, acute liver failure and death following acetaminophen overdose.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>

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