AZELASTINE-FLUTICASONE
  • AZELASTINE-FLUTICASONE (Generic for DYMISTA)

  • QTY 23 • 137-50 MCG • SPRAY/PUMP • Near 77381

AZELASTINE; FLUTICASONE (a ZEL as teen; floo TIK a sone) treats allergy symptoms such as sneezing, itching, or runny or stuffy nose. It works by blocking histamine, a substance released by the body during an allergic reaction. It also works by decreasing inflammation in the nose, making it easier to breathe. It is a combination of an antihistamine and a steroid.

AZELASTINE-FLUTICASONE (Generic for DYMISTA) Lifestyle Interactions

Azelastine Hydrochloride 137mcg/1actuation, Fluticasone Propionate 50mcg/1actuation, Nasal spray, suspension

Cannabis

· Severity: Major

· Notes for Consumers: Discuss cannabis use with your care team. The effects of your medication may be altered if used with cannabis. Call emergency services right away if you experience slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, or trouble staying awake.

· Notes for Professionals: Advise patients to avoid cannabis use while taking CNS depressants due to the risk for additive CNS depression and potential for other cognitive adverse reactions.

Azelastine Hydrochloride 137mcg/1actuation, Fluticasone Propionate 50mcg/1actuation, Nasal spray, suspension

Alcohol

· Severity: Major

· Notes for Consumers: Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication can cause serious side effects, such as central nervous system (CNS) depression, and can increase the risk of falling. Call emergency services right away if you experience symptoms of CNS depression: slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, trouble staying awake.

· Notes for Professionals: Advise patients to avoid alcohol consumption while taking CNS depressants. Alcohol consumption may result in additive CNS depression.

Azelastine Hydrochloride 137mcg/1actuation, Fluticasone Propionate 50mcg/1actuation, Nasal spray, suspension

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not eat grapefruit or drink grapefruit juice while taking Fluticasone without talking to your doctor or healthcare professional. Side effects from Fluticasone may get worse. Call your doctor or healthcare professional as soon as possible if you have side effects like roundness of the face, high blood pressure, extreme irritability, fainting, stomach pain, or water retention.

· Notes for Professionals: Instruct patients using inhaled fluticasone propionate products to avoid grapefruit juice. Patients using fluticasone furoate products should be aware of the potential for increased adverse effects if they regularly consume grapefruit juice. Increased systemic corticosteroid effects, including Cushing's syndrome and adrenal suppression, may occur. Fluticasone is a CYP3A4 substrate; grapefruit juice is a strong CYP3A4 inhibitor. In drug interaction studies, coadministration with strong inhibitors increased plasma fluticasone propionate exposure resulting in 45% to 86% decreases in serum cortisol AUC. A strong inhibitor increased fluticasone furoate exposure by 1.33-fold with a 27% reduction in weighted mean serum cortisol; this change does not necessitate dose adjustment of fluticasone furoate.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>

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