ACYCLOVIR; HYDROCORTISONE (ay SYE kloe veer; hye droe KOR ti sone) helps manage infections, such as cold sores, caused by viruses. It also decreases inflammation. It does not kill the virus and it may still be possible to spread the virus to others. It will not treat colds, the flu, or infections caused by bacteria.


XERESE Lifestyle Interactions

  • Acyclovir 5%, Hydrocortisone 1%, Topical cream

    Interaction: Grapefruit juice
    Severity: Major
    Notes for Consumers: Do not drink grapefruit juice or eat grapefruit while taking this medication. Grapefruit may alter the effects of your medication. Serious side effects may occur. Contact your care team right away if you experience new or worsening side effects.
    Notes for Professionals: Advise patients to avoid grapefruit and grapefruit juice during hydrocortisone treatment due to the risk of increased hydrocortisone exposure and adverse reactions. Hydrocortisone is a CYP3A substrate and grapefruit juice is a CYP3A inhibitor.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.