XARELTO
  • XARELTO

  • QTY 30 • 20 MG • Tablet • Near 77381

RIVAROXABAN (ri va ROX a ban) is an anticoagulant (blood thinner). It is used to treat blood clots in the lungs or in the veins. It is also used to prevent blood clots in the lungs or in the veins. It is also used to lower the chance of stroke in people with a medical condition called atrial fibrillation.

XARELTO Lifestyle Interactions

Rivaroxaban 20mg, Oral tablet

Alcohol

· Severity: Mild

· Notes for Consumers: Tell your health care professional if you drink alcohol. If you drink alcohol, rivaroxaban may not work as well for you. Immediately report any pain, swelling, redness, or warmth in a leg or difficulty breathing.

· Notes for Professionals: Use rivaroxaban cautiously in patients who consume alcohol. Coadministration of rivaroxaban and ethanol may result in decreased rivaroxaban exposure and may decrease the efficacy of rivaroxaban. Ethanol is an inducer of CYP3A4, and rivaroxaban is a substrate of CYP3A4. If a patient taking rivaroxaban also consumes alcohol, monitor the patient for signs of lack of efficacy of rivaroxaban.

Rivaroxaban 20mg, Oral tablet

Grapefruit juice

· Severity: Major

· Notes for Consumers: Tell your health care professional that you drink Grapefruit Juice before you take Rivaroxaban. If you drink Grapefruit Juice and take Rivaroxaban, your risk of bleeding is increased. Immediately report any unusual bleeding or bruising.

· Notes for Professionals: Avoid concomitant administration of rivaroxaban and grapefruit juice; significant increases in rivaroxaban exposure may increase bleeding risk. Rivaroxaban is a substrate of CYP3A4/5 and the P-glycoprotein (P-gp) transporter. Grapefruit juice is a combined P-gp inhibitor and strong CYP3A4 inhibitor. Concurrent use of a single dose of rivaroxaban and ritonavir, a combined P-gp and strong CYP3A4 inhibitor, led to an increase in the steady-state rivaroxaban AUC by 150% and to an increase in Cmax by 60%. Similar increases in pharmacodynamic effects such as factor Xa inhibition and PT prolongation were also observed.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

DISCLAIMER: This content is provided for informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.

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