• Image of Vivelle-Dot medication Image of Vivelle-Dot medication
    • ESTRADIOL (TWICE WEEKLY) (Generic for VIVELLE-DOT)

ESTRADIOL (es tra DYE ole) reduces the number and severity of hot flashes due to menopause. It may also help relieve the symptoms of menopause, such as vaginal irritation, dryness, or pain during sex. It can be used to prevent osteoporosis. It works by increasing levels of the hormone estrogen in the body. It is an estrogen hormone.


ESTRADIOL (TWICE WEEKLY) (Generic for VIVELLE-DOT) Lifestyle Interactions

  • Clopidogrel Bisulfate 75mg, Oral tablet

    Interaction: Grapefruit juice
    Severity: Major
    Notes for Consumers: Do not drink grapefruit juice or eat grapefruit while taking this medication. Grapefruit may alter the effects of your medication. Serious side effects may occur. Contact your care team right away if you experience new or worsening side effects.
    Notes for Professionals: Advise patients to avoid grapefruit and grapefruit juice during clopidogrel treatment due to the risk for increased clopidogrel exposure and adverse reactions. Clopidogrel is a CYP2C19 substrate and grapefruit juice is a CYP2C19 inhibitor.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.