THEOPHYLLINE

Theophylline, Anhydrous 80mg/15mL, Oral solution

Caffeine-containing Foods/Beverages

· Severity: Moderate

· Notes for Consumers: Side effects from Theophylline may get worse if you take too much Caffeine. Side effects may include nausea, irritability, nervousness, rapid heart-beat, tremors, or difficulty sleeping. Limit Caffeine intake while taking Theophylline. Common foods and beverages containing caffeine include coffee, teas, colas and chocolate. Many non-prescription drugs and diet aids may also contain caffeine. Discuss any new or worsening side effects with your health care provider.

· Notes for Professionals: Caffeine is a CNS stimulant. The concurrent administration of caffeine to patients taking theophylline may produce excessive caffeine-like side effects, such as nausea, irritability or nervousness. Adverse effects such as tremors, insomnia, seizures, or cardiac arrhythmias are also possible when excessive dosages of caffeine are taken concurrently with theophylline. Patients taking theophylline should avoid medications containing caffeine when possible. Patients may also need to limit their intake of caffeine-containing beverages or foods (e.g., coffee, green tea, other teas, colas, or chocolate) to avoid caffeine-like side effects.

Theophylline, Anhydrous 80mg/15mL, Oral solution

Cannabis

· Severity: Major

· Notes for Consumers: Discuss cannabis use with your care team. The effects of your medication may be altered if used with cannabis.

· Notes for Professionals: Advise patients to avoid cannabis use during theophylline treatment due to decreased exposure of theophylline which may alter its efficacy. Cannabis use induces CYP1A2 and theophylline is a CYP1A2 substrate. The induction potential of cannabis is greatest with chronic inhalation. Other routes of administration or sporadic use may have less of an effect. Chronic, inhaled cannabis use has been observed to increase theophylline clearance 1.4-fold.

Theophylline, Anhydrous 80mg/15mL, Oral solution

Tobacco

· Severity: Major

· Notes for Consumers: Do not smoke or use tobacco products while taking this medication. When used together, your medication may not work as well for you.

· Notes for Professionals: Advise patients to avoid smoking tobacco while taking theophylline. Smoking tobacco has been observed to decrease theophylline exposure by 50% to 100% and may result in loss of efficacy. Theophylline is a CYP1A2 substrate and smoking tobacco induces CYP1A2.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>