PERPHENAZINE-AMITRIPTYLINE
  • PERPHENAZINE-AMITRIPTYLINE

  • QTY 30 • 2 MG-25 MG • Tablet • Near 77381

PERPHENAZINE; AMITRIPTYLINE (per FEN a zeen; a mee TRIP ti leen) is used to treat depression that may be accompanied by anxiety or agitation. This medicine is also used to treat schizophrenia.

PERPHENAZINE-AMITRIPTYLINE Lifestyle Interactions

Amitriptyline Hydrochloride 25mg, Perphenazine 2mg, Oral tablet

Marijuana

· Severity: Major

· Notes for Consumers: Do not take Marijuana, Medical and Tricyclic Antidepressants together without talking to your health care provider. Taking these drugs together might increase the risk of high blood pressure or heart rate, nervousness, palpitations, problems with sleep, severe headache, or other side effects.

· Notes for Professionals: Avoid administering marijuana and tricyclic antidepressants together as concurrent use may result in adverse cardiovascular effects, such as tachycardia and cardiac arrhythmias. Marijuana is known to produce significant increases in heart rate and cardiac output lasting for 2 to 3 hours. Further, rare case reports of myocardial infarction and cardiac arrhythmias have been associated with marijuana use. Tricyclic antidepressants have also been reported to produce a wide range of cardiovascular effects including cardiac arrhythmias, palpitations, hypertension, ventricular tachycardia, heart failure, and stroke. Coadministration of marijuana with tricyclic antidepressants may result in significant cardiovascular adverse events and thus, should be avoided.

Amitriptyline Hydrochloride 25mg, Perphenazine 2mg, Oral tablet

Marijuana

· Severity: Major

· Notes for Consumers: It is recommended that ingestion, smoking, or inhalation of marijuana be avoided if you are treated with this drug. Marijuana may increase the risk for relapse or an increase in your mood and behavior symptoms. Marijuana may also interfere with the efficacy of your medication in treating your condition. If you continue to use marijuana, promptly get medical assistance if you experience unusual changes in moods or behaviors of any type. Be aware that sedation may occur and you should not drive or operate machinery or perform other hazardous tasks while under the influence of these medications.

· Notes for Professionals: It is recommended that patients avoid the use of marijuana, by any route, if they are treated for a psychiatric history, including psychosis and bipolar disorder, as the cannabinoids (the psychoactive ingredients, such as THC) in marijuana can produce psychotoxic effects and may exacerbate psychiatric disorders. A high frequency of use and use of products with high-potency of THC are potential risk factors for psychiatric effects. Additionally, additive CNS effects, such as sedation or CNS depression are possible. Clinical studies suggest that cannabis use may reduce the efficacy of some antipsychotic drugs. In addition, several cannabinoids in marijuana appear to influence the activity of CYP enzymes and P-glycoprotein, which may alter the concentrations of antipsychotics and influence either safety or efficacy, For example, the smoking of marijuana influences the metabolism of some medications in a manner similar to tobacco by inducing CYP1A2.

Amitriptyline Hydrochloride 25mg, Perphenazine 2mg, Oral tablet

Tobacco

· Severity: Moderate

· Notes for Consumers: Tobacco smoking may reduce the effectiveness of this drug in treating your condition; Tobacco smoke contains substances that speed the removal of this drug from the body. Alternatively, if you take this drug and suddenly stop Tobacco smoking, you may feel more drowsy or tired, or may experience confusion, dizziness, difficulty in movement or other side effects. If you will stop smoking, use care in driving or operating machinery until you know how this drug will affect you. Make sure your prescriber is aware that you smoke Tobacco or if you plan to stop smoking. Report any unusual side effects promptly.

· Notes for Professionals: Tobacco smoke may accelerate the metabolism of phenothiazines. Because the effect on hepatic microsomal enzymes is not related to the nicotine component of tobacco, the sudden cessation of tobacco smoking may result in a reduced clearance of these antipsychotics, despite the initiation of a nicotine replacement product. Monitor patients carefully when changes in smoking status occur.

Amitriptyline Hydrochloride 25mg, Perphenazine 2mg, Oral tablet

Tobacco

· Severity: Moderate

· Notes for Consumers: Tobacco smoking may reduce the effectiveness of this drug in treating your condition. Tobacco smoke contains substances that speed the removal of this drug from the body, which in theory can make this drug less effective. Alternatively, if you take this drug and suddenly stop Tobacco smoking, you may experience drug-related side effects like confusion, constipation, dizziness, difficulty with urination, dry mouth and eyes or drowsiness. Make sure your prescriber is aware that you smoke Tobacco or if you plan to stop smoking.

· Notes for Professionals: Tobacco smoking has been shown to increase the clearance of TCAs by inducing hepatic microsomal enzymes. Sudden smoking cessation may result in a reduced clearance of TCAs and increased TCA effects, despite the initiation of nicotine replacement products.

Amitriptyline Hydrochloride 25mg, Perphenazine 2mg, Oral tablet

Alcohol

· Severity: Major

· Notes for Consumers: It is recommended that you avoid Alcoholic drinks while you are taking this medication. Alcohol can increase the risk of side effects, such as drowsiness and dizziness. Do not drive or operate machinery if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.

· Notes for Professionals: Patients should generally be counseled to avoid alcohol use during phenothiazine therapy, due to additive central nervous system (CNS) depression and the potential to increase psychomotor impairment. Phenothiazines may increase, prolong, or intensify the sedative action of other CNS depressants, such as alcohol.

Amitriptyline Hydrochloride 25mg, Perphenazine 2mg, Oral tablet

Alcohol

· Severity: Moderate

· Notes for Consumers: It is recommended that you limit or avoid Alcoholic drinks while you are taking this medication. Alcohol can affect the mood and interfere with the drug treatment, and may increase the risk of side effects, such as sedation and dizziness. Do not drive or operate machinery if you are drinking alcohol-containing beverages.

· Notes for Professionals: Patients should be cautioned about using alcohol concurrently, since tricyclic antidepressants (TCAs) may exaggerate the CNS depressant response to alcohol, leading to an increase in sedation or psychomotor impairment. In some studies, alcohol has increased the unbound form of the TCA in the blood, which might be related to exagerrated clinical effect.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

DISCLAIMER: This content is provided for informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.

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