OXYCODONE-ACETAMINOPHEN
  • OXYCODONE-ACETAMINOPHEN (Generic for PERCOCET)

  • QTY 120 • 10MG-325MG • Tablet • Near 77381

ACETAMINOPHEN; OXYCODONE (a set a MEE noe fen; ox i KOE done) treats moderate pain. It is prescribed when other pain medications have not worked or cannot be tolerated. It works by blocking pain signals in the brain. This medication is a combination of acetaminophen and an opioid.

OXYCODONE-ACETAMINOPHEN (Generic for PERCOCET) Lifestyle Interactions

Oxycodone Hydrochloride 10mg, Acetaminophen 325mg, Oral tablet

Marijuana

· Severity: Major

· Notes for Consumers: Discuss marijuana use with your care team. The effects of your medication may be altered if used with marijuana. Call emergency services right away if you experience slow or shallow breathing, difficulty staying awake, or are unable to respond or wake up.

· Notes for Professionals: Advise patients to avoid marijuana use while taking CNS depressants due to the risk for additive CNS depression and potential for other cognitive adverse reactions.

Oxycodone Hydrochloride 10mg, Acetaminophen 325mg, Oral tablet

Alcohol

· Severity: Major

· Notes for Consumers: Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication increases the risk of liver injury. Contact your care team right away if you have right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, or unusual weakness or fatigue.

· Notes for Professionals: The risk of developing hepatotoxicity from acetaminophen appears to be increased in patients who regularly consume alcohol. Patients who drink more than 3 alcohol-containing drinks a day and take acetaminophen are at increased risk of developing hepatotoxicity. Acute or chronic alcohol use increases acetaminophen-induced hepatotoxicity by inducing CYP2E1 leading to increased formation of the hepatotoxic metabolite of acetaminophen. Also, chronic alcohol use can deplete liver glutathione stores. Administration of acetaminophen should be limited or avoided altogether in patients with alcoholism or patients who consume alcohol regularly.

Oxycodone Hydrochloride 10mg, Acetaminophen 325mg, Oral tablet

Grapefruit juice

· Severity: Moderate

· Notes for Consumers: It is recommended that you limit and do not significantly alter your intake of grapefruit or grapefruit juice while taking Oxycodone. Side effects from Oxycodone may get worse if you increase your intake of grapefruit juice. Talk to your doctor first. Contact your doctor right away if you have symptoms of Oxycodone side effects such as slurred speech, confusion, weakness, or trouble breathing. Do not drive or operate machinery until you know how Oxycodone affects you.

· Notes for Professionals: Patients should not significantly alter their intake of grapefruit or grapefruit juice duing therapy with oxycodone. Grapefruit juice, a strong CYP3A4 inhibitor, may increase plasma concentrations of oxycodone, a CYP3A4 substrate. This may increase or prolong oxycodone-related toxicities including respiratory depression. Advise patients accordingly; patient monitoring and dosage adjustments may be necessary if grapefruit is consumed regularly.

Oxycodone Hydrochloride 10mg, Acetaminophen 325mg, Oral tablet

Alcohol

· Severity: Major

· Notes for Consumers: Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication increases the risk of an opioid overdose. Symptoms of an overdose may include slow or shallow breathing, difficulty staying awake, or the inability to respond or wake up. Call emergency services right away if you experience these symptoms. Talk to your care team about naloxone, a medication for the emergency treatment of opioid overdose.

· Notes for Professionals: Advise patients to avoid alcohol consumption while taking opioids. Alcohol consumption may result in additive CNS depression and may increase the risk for opioid overdose. Consider the patient's use of alcohol when prescribing opioid medications. If the patient is unlikely to be compliant with avoiding alcohol, consider prescribing naloxone especially if additional risk factors for opioid overdose are present.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>

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