Doxycycline Monohydrate 40mg, Oral capsule, biphasic release
Calcium-containing foods
· Severity: Moderate
· Notes for Consumers: Take Doxycyline with plenty of fluid to reduce the risk of irritation to the stomach or esophagus (tube leading from mouth to stomach). For best results give Doxycycline at least 1 hour prior to or 2 hours after a meal and/or milk. Doxycycline may be taken with foods or milk if stomach irritation occurs.
· Notes for Professionals: Divalent or trivalent cations readily chelate with tetracycline antibiotics, forming insoluble compounds. The oral absorption of certain tetracycline class antibiotics will be reduced by agents containing these cations (e.g., calcium) and it is often recommended to avoid administration within 1 to 2 hours of interfering foods (e.g., dairy products). However, the oral absorption of doxycycline appears to be less affected by food interactions than tetracycline. Some manufacturers state that absorption of oral doxycycline is not markedly influenced by simultaneous ingestion of food or milk and recommend taking doxycycline with food or milk if gastric irritation occurs upon administration. However, there are studies describing altered doxycycline pharmacokinetics when given with meals containing dairy products. A single-dose study of Periostat given with a 1,000 calorie, high-fat, high-protein meal, which included dairy products, resulted in a decrease in the rate and extent of absorption and delay in the time to maximum concentrations. The dual-release capsules (Oracea) are not bioequivalent to other doxycycline products; absorption may be decreased when given with meals. In a single-dose food effect study, the Cmax and AUC of doxycycline (as Oracea) were reduced by about 45% and 22%, respectively, in healthy volunteers fed a 1,000 calorie, high-fat, high-protein meal which included dairy products. The reductions in AUC and Cmax can be clinically significant.
Doxycycline Monohydrate 40mg, Oral capsule, biphasic release
Foods High in Iron
· Severity: Moderate
· Notes for Consumers: Take Doxycyline with plenty of fluid to reduce the risk of irritation to the stomach or esophagus (tube leading from mouth to stomach). For best results give Doxycycline at least 1 hour prior to or 2 hours after a meal and/or milk. Doxycycline may be taken with foods or milk if stomach irritation occurs.
· Notes for Professionals: Divalent or trivalent cations readily chelate with tetracycline antibiotics, forming insoluble compounds. The oral absorption of certain tetracycline class antibiotics will be reduced by agents containing these cations (e.g., iron) and it is often recommended to avoid administration within at least 1 to 2 hours of interfering foods (e.g., foods containing high amounts of iron). However, the oral absorption of doxycycline appears to be less affected by food interactions than tetracycline. Some manufacturers state that absorption of oral doxycycline is not markedly influenced by simultaneous ingestion of food or milk and recommend taking doxycycline with food or milk if gastric irritation occurs upon administration. However, there are studies describing altered doxycycline pharmacokinetics when given with meals. A single-dose study of Periostat given with a 1,000 calorie, high-fat, high-protein meal, which included dairy products, resulted in a decrease in the rate and extent of absorption and delay in the time to maximum concentrations. The dual-release capsules (Oracea) are not bioequivalent to other doxycycline products; absorption may be decreased when given with meals. In a single-dose food effect study, the Cmax and AUC of doxycycline (as Oracea) were reduced by about 45% and 22%, respectively, in healthy volunteers fed a 1,000 calorie, high-fat, high-protein meal which included dairy products. The reductions in AUC and Cmax can be clinically significant.
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