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HARISIS Lifestyle Interactions
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Fluconazole 4%, Topical solution
• Interaction: Cannabis• Severity: Major• Notes for Consumers: Discuss cannabis use with your care team. The effects of cannabis may be altered if used with your medication. Call emergency services right away if you experience slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, or trouble staying awake.• Notes for Professionals: Advise patients to avoid cannabis use during fluconazole treatment. Concomitant use may alter the exposure of some cannabinoids and increase the risk for adverse reactions. The cannabinoid delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are CYP3A and CYP2C9 substrates and fluconazole is a moderate CYP3A and CYP2C9 inhibitor. -
Ibuprofen 2%, Topical solution
• Interaction: Alcohol• Severity: Major• Notes for Consumers: Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication increases the risk of stomach bleeding. Contact your care team right away if you experience bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds.• Notes for Professionals: Advise patients to avoid alcohol and alcohol-containing products while taking NSAIDs. Concomitant ingestion of alcohol with NSAIDs increases the risk of developing gastric irritation and GI mucosal bleeding. Alcohol is a mucosal irritant and NSAIDs decrease platelet aggregation. Routine ingestion of alcohol and NSAIDs can cause significant GI bleeding, which may or may not be overt. Even occasional concomitant use of NSAIDs and alcohol should be avoided. Chronic alcohol ingestion is often associated with hypoprothrombinemia and this condition increases the risk of bleeding. -
Ibuprofen 2%, Topical solution
• Interaction: Tobacco• Severity: Major• Notes for Consumers: Do not smoke or use tobacco products while taking this medication. Smoking while taking this medication increases the risk for stomach bleeding. Contact your care team right away if you experience bloody or black, tar-like stools, or vomiting blood or brown material that looks like coffee grounds.• Notes for Professionals: Advise patients to avoid smoking tobacco while taking nonsteroidal anti-inflammatory drugs (NSAIDs). Concomitant use of NSAIDs with tobacco smoking may enhance the risk of gastrointestinal side effects, including peptic ulcer and GI bleeding. Patients using tobacco and NSAIDs concurrently should be monitored closely for GI adverse reactions. -
Fluconazole 4%, Topical solution
• Interaction: Caffeine-containing Foods/Beverages• Severity: Moderate• Notes for Consumers: Although an interaction is possible, these drugs are often used together. Side effects from Caffeine may get worse if you take Fluconazole. Too much Caffeine can cause effects like nausea, nervousness, or sleeplessness. You may need to limit your Caffeine intake. Common foods and beverages containing caffeine include coffee, teas, colas and chocolate. Many non-prescription drugs and diet aids may also contain caffeine.• Notes for Professionals: Fluconazole has been shown to inhibit the clearance of caffeine by 25 percent. The clinical significance of these interactions has not been determined. -
Itraconazole 1%, Topical solution
• Interaction: Food• Severity: Moderate• Notes for Consumers: Itraconazole oral solution should be taken without food, while Itraconazole capsules should be taken with a full meal.• Notes for Professionals: Oral bioavailability of itraconazole from the capsules is increased if administered with a meal or cola beverage. Administration with orange juice should be avoided. -
Itraconazole 1%, Topical solution
• Interaction: Grapefruit juice• Severity: Mild• Notes for Consumers: It is best not to change your usual intake of grapefruit juice while taking Itraconazole. Grapefruit juice may decrease the actions of Itraconazole.• Notes for Professionals: Grapefruit juice reduced the mean peak itraconazole concentration by 35 percent when itraconazole capsules were administered with grapefruit juice in healthy volunteers; the AUC was reduced by an average of 43 percent compared to administration with water. Conversely, another study reported that grapefruit juice did not significantly affect the bioavailability of itraconazole capsules.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
