FLUCONAZOLE (Generic for DIFLUCAN)

FLUCONAZOLE (floo KON na zole) prevents and treats fungal infections. It belongs to a group of medications called antifungals. It will not treat colds, the flu, or infections caused by bacteria or viruses.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

Take this medication by mouth. Take it as directed on the prescription label at the same time every day. You can take it with or without food. If it upsets your stomach, take it with food. Take all of this medication unless your care team tells you to stop it early. Keep taking it even if you think you are better.
Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as newborns for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

Do not take this medication with the following:
-Alfuzosin
-Buprenorphine
-Cisapride
-Deuruxolitinib
-Flibanserin
-Lomitapide
-Lonafarnib
-Ondansetron
-Other medications that cause heart rhythm changes
-Quinine
-Red yeast rice
-Some antibiotics, such as clarithromycin or gepotidacin
-Some medications for cancer, such as ceritinib, crizotinib, dordaviprone, encorafenib, glasdegib, midostaurin, nilotinib, pacritinib, panobinostat, pazopanib, ribociclib, taletrectinib, toremifene, vemurafenib, zidesamtinib, ziftomenib
-Some medications for heart conditions, such as disopyramide, dofetilide, dronedarone, mavacamten, propafenone, quinidine
-Some medications for mental health conditions, such as citalopram, iloperidone, paliperidone, pimavanserin, pimozide, quetiapine, thioridazine, trazodone
This medication may also interact with the following:
-Abrocitinib
-Benzodiazepines, such as midazolam or triazolam
-Cannabis
-Ivacaftor
-Lemborexant
-NSAIDS, medications for pain and inflammation, such as celecoxib, ibuprofen, naproxen
-Some antibiotics, such as erythromycin, rifabutin, rifampin
-Some antivirals for HIV or hepatitis, such as zidovudine
-Some medications for blood pressure or heart disease, such as amlodipine, felodipine, hydrochlorothiazide, isradipine, losartan, nifedipine, verapamil
-Some medications for cancer, such as ibrutinib, olaparib, cyclophosphamide, vinblastine, vincristine
-Some medications for cholesterol, such as atorvastatin, fluvastatin, simvastatin
-Some medications for depression, anxiety, or other mental health conditions, such as amitriptyline, lurasidone, nortriptyline
-Some medications for diabetes, such as glyburide or glipizide
-Some medications for fungal infections, such as amphotericin B or voriconazole
-Some medications for seizures, such as carbamazepine or phenytoin
-Some medications that suppress the immune system, such as cyclosporine, sirolimus, tacrolimus
-Some opioids, such as alfentanil, fentanyl, methadone
-Steroid medications, such as prednisone
-Theophylline
-Tofacitinib
-Tolvaptan
-Vitamin A
-Warfarin
This medication may affect how other medications work, and other medications may affect the way this medication works. Talk with your care team about all the medications you take. They may suggest changes to your treatment plan to lower the risk of side effects and to make sure your medications work as intended.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

Visit your care team for regular checkups. If you are taking this medication for a long time you may need blood work. Tell your care team if your symptoms do not improve. Some fungal infections need many weeks or months of treatment to cure.
Alcohol can increase possible damage to your liver. Avoid alcoholic drinks.
If you have a vaginal infection, do not have sex until you have finished your treatment. You can wear a sanitary napkin. Do not use tampons. Wear freshly washed cotton, not synthetic, panties.

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Side effects that you should report to your care team as soon as possible:
-Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
-Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
-Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
-Low adrenal gland function—nausea, vomiting, loss of appetite, unusual weakness or fatigue, dizziness
-Rash, fever, and swollen lymph nodes
-Redness, blistering, peeling, or loosening of the skin, including inside the mouth
-Seizures
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
-Change in taste
-Diarrhea
-Dizziness
-Headache
-Nausea
-Stomach pain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Keep out of the reach of children and pets.
Store at room temperature below 30 degrees C (86 degrees F). Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
-Take the medication to a take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix it with cat litter, dirt, coffee grounds, or another unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.