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ELYZIA
- QTY 28
- 0.1 %-4 %
- Ointment
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ELYZIA
- QTY 28
- 0.1 %-4 %
- Ointment
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ELYZIA Lifestyle Interactions
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Tacrolimus 0.1%, Topical ointment
• Interaction: Alcohol• Severity: Major• Notes for Consumers: Do not drink alcohol while taking this medication. Drinking alcohol may alter the effects of your medication. Serious side effects may occur. Contact your care team if you experience new or worsening side effects.• Notes for Professionals: Alcohol-containing beverages should not be consumed while taking the extended-release tacrolimus capsules (Astagraf XL). Concomitant alcohol use may increase the rate of release of tacrolimus and/or adversely alter the pharmacokinetic properties and effectiveness and safety. A flushing syndrome (alcohol intolerance) has been reported in patients treated with topical tacrolimus upon ingestion of alcohol. The flushing occurred in the face or at the sites of medication application, usually within 5 to 15 minutes of alcohol ingestion, and lasted for an average duration of 1 hour. Patients describe redness and warm sensations, which sometimes result in discomfort. The reaction does not appear to occur in all patients; roughly 3% to 7% report a notable effect. The possible mechanism of the effect is the inhibition of acetaldehyde dehydrogenase, leading to increased acetaldehyde dehydrogenase concentrations in the skin. -
Tacrolimus 0.1%, Topical ointment
• Interaction: Grapefruit juice• Severity: Major• Notes for Consumers: Do not drink grapefruit juice or eat grapefruit while taking this medication. Grapefruit may alter the effects of your medication. Serious side effects may occur. Contact your care team right away if you experience new or worsening side effects.• Notes for Professionals: Advise patients to avoid grapefruit and grapefruit juice during tacrolimus treatment due to the risk for increased tacrolimus exposure and adverse reactions. Tacrolimus is a CYP3A substrate and grapefruit juice is a CYP3A inhibitor. -
Niacinamide 4%, Topical ointment
• Interaction: Food• Severity: Moderate• Notes for Consumers: Avoid drinking hot beverages or eating hot food around the times you take Niacin. Ingesting hot food or beverages may worsen skin flushing (example: warm and reddened skin of the face, neck, or chest) while taking Niacin. Alcoholic beverages may also have this effect, so also avoid drinking alcohol around the time of your Niacin dose. Taking Niacin with meals may help to decrease skin flushing.• Notes for Professionals: Hot beverages and foods can exacerbate cutaneous vasodilation caused by niacin and should be avoided around the time of niacin ingestion. In general, this interaction would not be harmful, but might decrease patient tolerance of niacin.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
