DIDANOSINE

Didanosine 250mg, Oral capsule, gastro-resistant pellets

Food

· Severity: Major

· Notes for Consumers: Didanosine, ddI, should be given 30 minutes before or 2 hours after meals.

· Notes for Professionals: Food interactions are possible with didanosine, ddI, and it should not be taken with food. Didanosine is acid-labile and susceptible to degradation by stomach acid. Absorption from the GI tract therefore varies among individuals and is also affected by the dosage form, presence of food, and gastric pH. The manufacturer recommends that all didanosine products be given on an empty stomach 30 minutes before or 2 hours after meals. Administration up to 2 hours after a meal reduces peak blood levels and AUC by 55%. To improve adherence, some practitioners administer didanosine without regard to food administration. In a study comparing fed and fasting state administration in children (n=106), overall systemic exposure (AUC) was similar between groups with slower absorption and prolonged elimination noted during the administration of food. Additionally, studies in adults suggest that it may be given without regard to food.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>