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DARATUMUMAB; HYALURONIDASE (DAR a TOOM ue mab; hye al ur ON i dase) treats multiple myeloma, a type of bone marrow cancer. Daratumumab works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells. Hyaluronidase helps your body absorb this medication. This helps it work better in your body. This medication may also be used treat amyloidosis, a condition that causes the buildup of a protein (amyloid) in your body. It works by reducing the buildup of this protein, which decreases symptoms. It is a combination medication that contains a monoclonal antibody.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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This medication is injected under the skin. It is given by your care team in a hospital or clinic setting.
Talk to your care team about the use of this medication in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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Interactions have not been studied.
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Your condition will be monitored carefully while you are receiving this medication.
This medication can cause serious allergic reactions. To reduce the risk, your care team may give you other medication to take before receiving this one. Follow the directions from your care team.
This medication may increase your risk of getting an infection. Call your care team for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.
This medication can affect the results of blood tests to match your blood type. These changes can last for up to 6 months after your last dose. Your care team will do blood tests to match your blood type before you start treatment. Tell all of your care teams that you are being treated with this medication before receiving a blood transfusion.
Talk to your care team if you may be pregnant. Serious fetal side effects can occur if you take this medication during pregnancy and for 3 months after the last dose. Contraception is recommended while taking this medication and for 3 months after the last dose. Your care team can help you find the option that works for you.
Do not breastfeed while taking this medication.
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Keep appointments for follow-up doses. It is important not to miss your dose. Call your care team if you are unable to keep an appointment.
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Side effects that you should report to your care team as soon as possible:
-Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
-Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
-Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
-Infusion reactions—chest pain, shortness of breath or trouble breathing, feeling faint or lightheaded
-Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
-Unusual bruising or bleeding
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
-Constipation
-Diarrhea
-Fatigue
-Nausea
-Pain, tingling, or numbness in the hands or feet
-Swelling of the ankles, hands, or feet
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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This medication is given in a hospital or clinic. It will not be stored at home.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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