• Image of Aleve PM medication Image of Aleve PM medication
    • ALEVE PM

    • QTY 20
    • 220MG-25MG
    • Tablet
    • Near  77381

DIPHENHYDRAMINE; NAPROXEN (dye fen HYE dra meen; na PROX en) treats pain and helps you go to sleep faster. It is a combination of an antihistamine and an NSAID.


ALEVE PM Lifestyle Interactions

  • Naproxen Sodium 220mg, Diphenhydramine Hydrochloride 25mg, Oral tablet

    Interaction: Cannabis
    Severity: Major
    Notes for Consumers: Discuss cannabis use with your care team. The effects of your medication may be altered if used with cannabis. Call emergency services right away if you experience slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, or trouble staying awake.
    Notes for Professionals: Advise patients to avoid cannabis use while taking CNS depressants due to the risk for additive CNS depression and potential for other cognitive adverse reactions.
  • Naproxen Sodium 220mg, Diphenhydramine Hydrochloride 25mg, Oral tablet

    Interaction: Alcohol
    Severity: Major
    Notes for Consumers: Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication can cause serious side effects, such as central nervous system (CNS) depression, and can increase the risk of falling. Call emergency services right away if you experience symptoms of CNS depression: slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, trouble staying awake.
    Notes for Professionals: Advise patients to avoid alcohol consumption while taking CNS depressants. Alcohol consumption may result in additive CNS depression.
  • Naproxen Sodium 220mg, Diphenhydramine Hydrochloride 25mg, Oral tablet

    Interaction: Tobacco
    Severity: Major
    Notes for Consumers: Do not smoke or use tobacco products while taking this medication. Smoking while taking this medication increases the risk for stomach bleeding. Contact your care team right away if you experience bloody or black, tar-like stools, or vomiting blood or brown material that looks like coffee grounds.
    Notes for Professionals: Advise patients to avoid smoking tobacco while taking nonsteroidal anti-inflammatory drugs (NSAIDs). Concomitant use of NSAIDs with tobacco smoking may enhance the risk of gastrointestinal side effects, including peptic ulcer and GI bleeding. Patients using tobacco and NSAIDs concurrently should be monitored closely for GI adverse reactions.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.