ACT DRY MOUTH Lifestyle Interactions

  • Relugolix 40mg, Estradiol 1mg, Norethindrone Acetate 0.5mg, Oral tablet

    • Interaction: Grapefruit juice
    • Severity: Major
    • Notes for Consumers: Do not take Relugolix with grapefruit or grapefruit juice. Side effects of Relugolix may get worse. If you accidentally take Relugolix with grapefruit or grapefruit juice, immediately tell your doctor about any unusual effects including chest pain, dizziness, fainting or falling spells, palpitations, shortness of breath, or a change in your heartbeat (such as a fast or irregular heartbeat).
    • Notes for Professionals: Instruct patients to avoid grapefruit or grapefruit juice with relugolix due to increased plasma concentrations of relugolix, which may increase the incidence and severity of adverse reactions. Relugolix is a P-glycoprotein (P-gp) substrate; grapefruit juice is a P-gp inhibitor.

  • Relugolix 40mg, Estradiol 1mg, Norethindrone Acetate 0.5mg, Oral tablet

    • Interaction: Tobacco
    • Severity: Major
    • Notes for Consumers: Do not smoke or use tobacco products while taking this medication. Smoking while taking this medication increases the risk for serious side effects such as blood clots, heart attack, and stroke. Call emergency services right away if you experience symptoms of a blood clot in your lung: shortness of breath or chest pain. You should also call emergency services right away if you experience symptoms of a heart attack: pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded. You should also call emergency services right away if you experience symptoms of a stroke: sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision. Contact your care team right away if you experience symptoms of a blood clot in your leg: pain, swelling, or warmth in the leg.
    • Notes for Professionals: Advise patients to avoid cigarette smoking while taking estrogen hormones. Cigarette smoking increases the risk of serious cardiovascular events, such as myocardial infarction, stroke, deep vein thrombosis, and pulmonary embolism. Combined hormonal contraceptives are contraindicated in females who are over 35 years of age and smoke.

  • Relugolix 40mg, Estradiol 1mg, Norethindrone Acetate 0.5mg, Oral tablet

    • Interaction: Alcohol
    • Severity: Moderate
    • Notes for Consumers: Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication increases the risk for serious side effects. Contact your care team if you experience new or worsening side effects.
    • Notes for Professionals: Advise patients to limit alcohol intake while taking estradiol; an estradiol dosage adjustment may be required for some patients based on response. Concomitant use may increase estradiol concentrations. Acute alcohol ingestion in postmenopausal patients receiving estradiol replacement therapy has been observed to increase circulating estradiol levels by 3-fold.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.