TOLTERODINE TARTRATE ER (Generic for DETROL LA)

Tolterodine Tartrate 4mg, Oral capsule, extended release

Caffeine-containing Foods/Beverages

· Severity: Mild

· Notes for Consumers: The intake of beverages containing caffeine may decrease the actions of Tolterodine because Caffeine may increase urination. You may wish to limit your caffeine intake (including intake of coffee, colas, teas, or herbal supplements) while taking Tolterodine.

· Notes for Professionals: Beverages containing caffeine may aggravate bladder symptoms and counteract the effectiveness of tolterodine to some degree. Patients may wish to limit their intake of caffeinated drugs, dietary supplements, or beverages.

Tolterodine Tartrate 4mg, Oral capsule, extended release

Grapefruit juice

· Severity: Mild

· Notes for Consumers: Side effects from Tolterodine may get worse if you take grapefruit juice. Do not significantly alter your intake of grapefruit or grapefruit juice while taking Tolterodine. Discuss any new or worsening side effects, such as constipation, dizziness, difficulty with urination, dry mouth and eyes, changes in vision, fast heartbeat, or confusion, with your health care provider.

· Notes for Professionals: In a small portion of patients who poorly metabolize tolterodine via CYP2D6, the CYP3A4 pathway becomes important in tolterodine elimination. Grapefruit and grapefruit juice inhibit CYP3A4 metabolism in gut enterocytes. Patients should not significantly adjust their intake of grapefruit or grapefruit juice while taking tolterodine. Consideration should be given to limiting tolterodine dosage to 2 mg/day in some patients.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>