TEGRETOL XR (Brand for CARBAMAZEPINE ER)

Carbamazepine 200mg, Oral tablet, extended release

Enteral Feedings

· Severity: Moderate

· Notes for Consumers: Enteral feedings may decrease the actions of Carbamazepine oral suspension. To avoid an interaction with liquid nutrition products, take Carbamazepine oral suspension at least 15 minutes before or 15 minutes after you take tube feedings or nutritional supplement beverages (examples: Ensure, Jevity, and others). Enteral feedings do not appear to interact with Carbamazepine tablets or capsules.

· Notes for Professionals: Concurrent enteral feedings appear to slow or impede the absorption of carbamazepine suspension from the GI tract. Where possible, hold continuous enteral feedings at least 15 minutes before and 15 minutes after the administration of a carbamazepine suspension dose. Flush enteral tubes with appropriate volumes of water or other compatible fluid before and after carbamazepine suspension administration.

Carbamazepine 200mg, Oral tablet, extended release

Cannabis

· Severity: Major

· Notes for Consumers: Discuss cannabis use with your care team. The effects of cannabis may be altered if used with your medication.

· Notes for Professionals: Advise patients to avoid cannabis use during carbamazepine treatment. Concomitant use may decrease the concentration of some cannabinoids and alter their effects. The cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are CYP3A substrates and carbamazepine is a strong CYP3A inducer. Concomitant use of a cannabinoid product containing THC and CBD at an approximate 1:1 ratio with another strong CYP3A inducer decreased THC, 11-OH-THC, and CBD peak exposures by 36%, 87%, and 52% respectively.

Carbamazepine 200mg, Oral tablet, extended release

Grapefruit juice

· Severity: Moderate

· Notes for Consumers: Grapefruit juice and grapefruit-containing foods may increase the effects of Carbamazepine. Do not significantly alter your intake of grapefruit juice while taking this drug.

· Notes for Professionals: Grapefruit juice has been shown to increase carbamazepine peak and trough serum concentrations and the AUC by up to 40 percent. Grapefruit juice contains a compound that inhibits CYP3A4 in enterocytes. Increased sedation or other side effects may be possible. It is recommended that patients not significantly alter their grapefruit ingestion while taking carbamazepine.

Carbamazepine 200mg, Oral tablet, extended release

Alcohol

· Severity: Major

· Notes for Consumers: Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication can cause serious side effects, such as central nervous system (CNS) depression, and can increase the risk of falling. Call emergency services right away if you experience symptoms of CNS depression: slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, trouble staying awake.

· Notes for Professionals: Advise patients to avoid alcohol consumption while taking CNS depressants. Alcohol consumption may result in additive CNS depression.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>