ST. JOHNS WORT

St. John's Wort (Hypericum Perforatum) 300mg, Oral capsule

Cannabis

· Severity: Major

· Notes for Consumers: Discuss cannabis use with your care team. The effects of cannabis may be altered if used with your medication.

· Notes for Professionals: Advise patients to avoid cannabis use if they are taking St. John's wort. Concomitant use may decrease the concentration of some cannabinoids and alter their effects. The cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are CYP3A substrates and St. John's wort is a strong CYP3A inducer. Concomitant use of a cannabinoid product containing THC and CBD at an approximate 1:1 ratio with another strong CYP3A inducer decreased THC, 11-OH-THC, and CBD peak exposures by 36%, 87%, and 52% respectively.

St. John's Wort (Hypericum Perforatum) 300mg, Oral capsule

Tyramine-containing foods

· Severity: Mild

· Notes for Consumers: Food interactions with St. John's wort are thought to be unlikely. You may wish to limit your intake of alcoholic beverages, aged or smoked meats, or aged cheeses while on this herb as a precaution, but there is no evidence to suggest this is necessary. St. John's wort may also decrease the actions of caffeine, but serious interactions are not expected.

· Notes for Professionals: Since some compounds in St. John's wort may potentially inhibit MAO, the ingestion of tyramine-containing foods, like aged or smoked meats, yeast, cheeses, pickled herring, should be minimized when using St. John's wort.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>