PERPHENAZINE; AMITRIPTYLINE (per FEN a zeen; a mee TRIP ti leen) treats depression and anxiety. It may also be used to treat schizophrenia. It works by increasing levels of dopamine, norepinephrine, and serotonin in your brain, substances that help regulate mood, behaviors, and thoughts. It is a combination of an antipsychotic and a tricyclic antidepressant (TCA). Antipsychotic medications can be used to treat several kinds of mental health conditions.

PERPHENAZINE-AMITRIPTYLINE Lifestyle Interactions

  • Amitriptyline Hydrochloride 25mg, Perphenazine 2mg, Oral tablet

    • Interaction: Alcohol
    • Severity: Major
    • Notes for Consumers: Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication can cause serious side effects, such as central nervous system (CNS) depression, and can increase the risk of falling. Call emergency services right away if you experience symptoms of CNS depression: slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, trouble staying awake.
    • Notes for Professionals: Advise patients to avoid alcohol consumption while taking CNS depressants such as tricyclic antidepressants (TCAs). TCAs may exaggerate the CNS depressant response to alcohol, leading to an increase in sedation or psychomotor impairment. In some studies, alcohol has increased the unbound form of the TCA in the blood, which might be related to exaggerated clinical effect.

  • Amitriptyline Hydrochloride 25mg, Perphenazine 2mg, Oral tablet

    • Interaction: Tobacco
    • Severity: Major
    • Notes for Consumers: Do not smoke or use tobacco products while taking this medication. When used together, your medication may not work as well for you.
    • Notes for Professionals: Advise patients to avoid smoking tobacco while taking tricyclic antidepressants (TCAs). Tobacco smoking may increase the clearance of TCAs, which may reduce their efficacy.

  • Amitriptyline Hydrochloride 25mg, Perphenazine 2mg, Oral tablet

    • Interaction: Cannabis
    • Severity: Major
    • Notes for Consumers: Discuss cannabis use with your care team. The effects of your medication may be altered if used with cannabis. Call emergency services right away if you experience slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, or trouble staying awake.
    • Notes for Professionals: Advise patients to avoid cannabis use while taking CNS depressants due to the risk for additive CNS depression and potential for other cognitive adverse reactions.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.