METHYLPREDNISOLONE ACETATE (Generic for DEPO-MEDROL)

Methylprednisolone Acetate 80mg/1mL, Suspension for injection

Grapefruit juice

· Severity: Moderate

· Notes for Consumers: In theory, grapefruit juice and grapefruits might increase the side effects of Methylprednisolone, but it is not clear if this interaction is significant. If possible, avoid ingesting grapefruit juice while taking Methylprednisolone. At the very least, do not significantly change your daily intake of grapefruit and grapefruit juice.

· Notes for Professionals: Grapefruit juice may enhance steroid effects if taken with oral methylprednisolone. Grapefruit juice contains a compound that inhibits CYP3A4 in enterocytes; decreased methylprednisolone metabolism is the probable mechanism. Methylprednisolone peak concentrations and AUC increased and the half-life of methylprednisolone was prolonged in one study of the interaction. The clinical significance of the interaction is uncertain. Patients should be advised to not significantly alter their grapefruit juice ingestion.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>